June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Evaluation of Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy using OCT-based Microangiography
Author Affiliations & Notes
  • Ruikang K Wang
    Bioengineering, University of Washington, Seattle, WA
  • Qinqin Zhang
    Bioengineering, University of Washington, Seattle, WA
  • Cecilia Lee
    Ophthalmology, University of Washington, Seattle, WA
  • Yanping Huang
    Bioengineering, University of Washington, Seattle, WA
  • Kasra Attaran Rezaei
    Ophthalmology, University of Washington, Seattle, WA
  • Richard Munsen
    Ophthalmology, University of Washington, Seattle, WA
  • Jennifer R Chao
    Ophthalmology, University of Washington, Seattle, WA
  • James L Kinyoun
    Ophthalmology, University of Washington, Seattle, WA
  • Footnotes
    Commercial Relationships Ruikang Wang, Carl Zeiss Meditec Inc (F), Carl Zeiss Meditec Inc (P); Qinqin Zhang, Carl Zeiss Meditec (F); Cecilia Lee, None; Yanping Huang, None; Kasra Attaran Rezaei, None; Richard Munsen, None; Jennifer Chao, None; James Kinyoun, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3355. doi:
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    • Get Citation

      Ruikang K Wang, Qinqin Zhang, Cecilia Lee, Yanping Huang, Kasra Attaran Rezaei, Richard Munsen, Jennifer R Chao, James L Kinyoun, ; Evaluation of Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy using OCT-based Microangiography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3355.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To assess the feasibility and proficiency of OCT-based microangiography (OMAG) in the detection and visualization of vascular involvement at different stages of age-related macular degeneration (AMD).

 
Methods
 

Twenty patients were recruited, including early stage AMD, geographic atrophy (GA), neovascular AMD and polypoidal choroidal vasculopathy (PCV). Patients were scanned by a Zeiss OCT-angiography prototype with motion tracking. OCT scans centered on the fovea were captured to generate the OMAG images. OMAG images were segmented into 4 layers including the inner (GCL->IPL), deeper (INL->photoreceptor layer) retinal layers, choriocapillaris, and deeper choroidal layer. Enface images were used to represent angiograms at different layers (coded with different colors for visual purposes).

 
Results
 

Enface OMAG images showed overall good agreement with fluorescein angiography (FA). OMAG gave more detailed visualization of vascular networks that were less affected by subretinal hemorrhages. In early stage AMD, small drusen were observed, but retinal vessels seemed the same as for normal subjects. For patients with GA, abnormalities of the RPE layer resulted in the ability to easily observe the choriocapillaris and large choroidal vessels. Feeding and draining vessels were identified in neovascular AMD and PCV. Choroidal neovascularization (CNV) was more demarcated by OMAG as compared to FA due to the late leakage of fluorescein dye which obscures the CNV.

 
Conclusions
 

OMAG provides depth-resolved and detailed vascular images of AMD. In most cases, proper segmentation is the key to identifying the location of abnormal vessels. Our ongoing studies with OMAG will standardize quantification of the retinal and choroidal vascular layers during the progression of AMD as well as following treatment, particularly with anti-VEGF agents.  

 
PCV of serosanguineous PEDs from 72-year old patient. (A, B) are the early and late phase FA images; (C) The color OMAG image from retina to choroid overlying the FA image; (D) The magnified FA image corresponding to the OMAG images; (E) The vasculature within inner (red) and deeper (green) retinal layer. (F) The vasculature from RPE to choroid layers. (G) The cross-sectional structure image at the position marked by the white line in (E, F) overlying flow image; color coding scheme is shown.
 
PCV of serosanguineous PEDs from 72-year old patient. (A, B) are the early and late phase FA images; (C) The color OMAG image from retina to choroid overlying the FA image; (D) The magnified FA image corresponding to the OMAG images; (E) The vasculature within inner (red) and deeper (green) retinal layer. (F) The vasculature from RPE to choroid layers. (G) The cross-sectional structure image at the position marked by the white line in (E, F) overlying flow image; color coding scheme is shown.

 
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