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Liang Liu, Yali Jia, David Huang, Phoebe Lin, Alex David Pechauer, Eric B Suhler; Angiography of Peripapillary Retina in Retinal Vasculitiswith 70 kHz Spectral OCT. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3360.
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© ARVO (1962-2015); The Authors (2016-present)
To compare peripapillary retinal perfusion between normal and retinal vasculitis subjects using a commercially available optical coherence tomography (OCT) system
Each study participant was imaged using a 3x3 mm angiography scan by a high-speed (70 kHz) 840 nm spectrometer-based OCT system. The split-spectrum amplitude decorrelation angiography (SSADA) algorithm was used to compute angiograms. The peripapillary retinal flow index and vessel density were calculated in the 700µm wide annulus extending outward from the optic disc boundary. The flow index was defined as the average decorrelation value on the retinal angiogram in the annulus region. The peripapillary retinal vessel density was defined as the percentage area occupied by vessels. Mann-Whitney test was used to compare these perfusion variables between vasculitis patients and normal subjects
The study included 7 normal(7 eyes) and 4 retinal vasculitis patients(5 eyes). In the normal eye, a dense microvascular network around disc was visible on OCT angiography (Fig. B). This network was visibly attenuated in the vasculitis eyes, and focal capillary dropout was detected (Fig. E, F). In normal participants, the population variability of peripapillary retinal flow index and vessel density was 6.5% and 1.5% coefficient of variation (CV) respectively. In the vasculitis participants, the peripapillary retinal flow index was 0.085 ± 0.005 (mean ± SD), which was significantly less (P<0.05) than that of the normal group (0.094 ± 0.006). The vessel density in the vasculitis participants was 85.2% ± 1.3% (mean ± SD), which was significantly less (P<0.01) than that of the normal group (90.9% ± 1.3%)
High quality OCT angiograms of peripapillary retina could be obtained in both normal and retinal vasculitis participants. Retinal vasculitis reduction in peripapillary perfusion could be visualized as focal defects and quantified as flow index and vessel density. OCT angiography could be useful in the clinical evaluation of retinal vasculitis.
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