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Hee Jung Kwon, Jimin Ahn, Christopher Seungkyu Lee, Min Kim, SungChul Lee; Treatment of subretinal fluid associated with choroidal nevus. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3446.
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© ARVO (1962-2015); The Authors (2016-present)
To report the outcomes of 15 patients with subretinal fluid associated with choroidal nevus.
The medical records of 15 patients who diagnosed with choroidal nevus between December 2005 and July 2014 were retrospectively reviewed. All patients were examined with fluorescein angiography, fundus photo, B-scan ultrasonography and optical coherence tomography. Patients were treated with intravitreal bevacizumab (IVB) and/or transpupillary thermotherapy (TTT) or observed without treatment. Data were analyzed to evaluate outcomes of treatment response and visual acuity.
Fifteen patients were included in this study. Of this, eight patients were treated with only IVB, two patients with only TTT, four patients with TTT following IVB and one patient observed without treatment. Visual acuity improved in four eyes by more than 2 Snellen lines, remained stable in six eyes, and worsened in five eyes by more than 2 Snellen lines. Among twelve patients who treated with IVB (1~6 injections), only one patient showed complete subretinal fluid reduction on OCT but no vision improvement was observed. Two patients who treated with TTT showed complete fluid absorption and vision improvement. Among 4 patients who treated with TTT and IVB, one patient showed complete fluid absorption after TTT, which did not respond to IVB. Spontaneous subretinal fluid absorption was observed in two patients (one patient; without treatment, one patient; 3 years after last IVB). Six choroidal nevus demonstrated tumor growth after IVB and treated with brachytherapy or enucleation.
Intravitreal bevacizumab injection showed no sufficient effect in reducing vision threatening subretinal fluid associated with choroidal nevus, but transpupillary thermotherapy seems effective in reducing fluid and improving vision. Spontaneous subretinal fluid absorption may occur without treatment. The growth of chorodial nevus was noted and treated as choroidal melanoma, so careful monitoring for tumor growth is necessary.
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