June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Cytokine Profile TH1 / TH2 / TH17 in aqueous humor of patients with Primary Open Angle Glaucoma (POAG) and primary angle closure glaucoma (PACG) compared with patients Healthy controls.
Author Affiliations & Notes
  • Ana Paola Lopez-Venegas
    Retina, Instituto de Oftalmologia - Conde de Valenciana, Mexico City, Mexico
  • Maria Elena Mendoza-Mendieta
    Retina, Instituto de Oftalmologia - Conde de Valenciana, Mexico City, Mexico
  • Victor Manuel Bautista
    Retina, Instituto de Oftalmologia - Conde de Valenciana, Mexico City, Mexico
  • Footnotes
    Commercial Relationships Ana Lopez-Venegas, None; Maria Mendoza-Mendieta, None; Victor Bautista, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3481. doi:
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      Ana Paola Lopez-Venegas, Maria Elena Mendoza-Mendieta, Victor Manuel Bautista; Cytokine Profile TH1 / TH2 / TH17 in aqueous humor of patients with Primary Open Angle Glaucoma (POAG) and primary angle closure glaucoma (PACG) compared with patients Healthy controls.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3481.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To compare the profile of TH1 / TH2 / TH17 in Aqueous Humor of patients with POAG and PACG compared with healthy controls.

Methods: Aqueous humor of patients with POAG and PACG trabeculectomy operated and healthy controls operated for cataract surgery (10 patients in each group) was obteined and was measured by flow cytometry levels of IL2, IL4, IL6, IL-10, TNF, INFG, and IL17. Data analysis was performed with FCAP Array software. The interpretation of results was performed with the Prism program using the Bonferroni multiple comparison test.

Results: An increase of IL-17 in aqueous humor of patients with GPAC compared with healthy controls was found with p <0.05, likewise a trend towards lower IL-6 was found with p> 0.05.

Conclusions: The present study shows that the primary glaucoma may be associated with changes in the profile of cytokines in aqueous humor being, different cytokine profile of POAG and PACG, the latter with a TH17 response. This is the first study that found a significant elevation of IL-17 in aqueous humor of patients with glaucoma, which suggests that in these patients a chronic inflammatory process most likely related to the mechanism of apposition iridotrabecular unlike POAG patients in which there is no such mechanism.

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