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Jing Feng, Xiaoxue Zheng, Yanrong Jiang; Differences in Aqueous Concentrations of Cytokines in Pediatric and Adult patients with Coats’ disease. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3502.
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To investigate the differential aqueous concentrations of VEGF and inflammatory cytokines in pediatric and adult patients with Coats’ disease.
A total of 19 eyes of 19 patients with Coats’ disease, 11 eyes of 11 pediatric patients, and 8 eyes of 8 adult patients, 6 patients (6 eyes) with congenital cataract and 9 patients (9 eyes) with senile cataract as the control group were examined. Aqueous humor samples were assessed for interleukin 6, 8, 1β (IL-6, IL-8, IL-1β, respectively), basic fibroblast growth factor (bFGF), monocyte chemoattractant protein 1 (MCP1), tumor necrosis factor alpha (TNFα), and vascular endothelia growth factor (VEGF) by multiplex bead assay.
Significantly higher concentrations of VEGF，TNFα，IL-8，IL-6，IL-1β were found in pediatric patients with Coats’ disease (P=0.002, P=0.026, P=0.036, P=0.008, and P=0.010). Concentration of VEGF in pediatric patients with 3b stage of Coats’ disease was significantly higher than that of 3a stage (P=0.008). In adult patients with Coats’ disease, the aqueous levels of IL-8, IL-6 and IL-1β were significantly higher than that of the controls (P=0.036，P=0.008, and P=0.010). The concentration of IL-6 was significantly associated with the extent of exudative retinal detachment (P=0.02, R2=0.901). Compared with pediatric patients, the VEGF level in the aqueous humor of adult patients was significantly lower (P=0.011).
Besides VEGF, IL-6 as a major protein involved in Inflammation may be associated with Coats’ disease, especially in adult patients.
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