June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Frequency of glaucoma and its associations in a large cohort, UK Biobank
Author Affiliations & Notes
  • Fang Ko
    Glaucoma, Moorfields Eye Hospital, London, United Kingdom
    Institute of Ophthalmology, University College of London, London, United Kingdom
  • Nicholas G Strouthidis
    Institute of Ophthalmology, University College of London, London, United Kingdom
    NIHR Biomedical Research Centre in Ophthlamology, Moorfields Eye Hospital, London, United Kingdom
  • Praveen J Patel
    Institute of Ophthalmology, University College of London, London, United Kingdom
    NIHR Biomedical Research Centre in Ophthlamology, Moorfields Eye Hospital, London, United Kingdom
  • Jennifer L Y Yip
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
  • Zaynah Muthy
    Institute of Ophthalmology, University College of London, London, United Kingdom
  • Peng Tee Khaw
    Institute of Ophthalmology, University College of London, London, United Kingdom
    NIHR Biomedical Research Centre in Ophthlamology, Moorfields Eye Hospital, London, United Kingdom
  • Paul J Foster
    Institute of Ophthalmology, University College of London, London, United Kingdom
    NIHR Biomedical Research Centre in Ophthlamology, Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships Fang Ko, None; Nicholas Strouthidis, Alcon (R), Allergan (R), Heidelberg Engineering (R), Novartis (R); Praveen Patel, None; Jennifer Yip, None; Zaynah Muthy, None; Peng Khaw, None; Paul Foster, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3695. doi:
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      Fang Ko, Nicholas G Strouthidis, Praveen J Patel, Jennifer L Y Yip, Zaynah Muthy, Peng Tee Khaw, Paul J Foster, ; Frequency of glaucoma and its associations in a large cohort, UK Biobank. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3695.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine frequency of reported glaucoma and its associations in a cohort of 112,690 people.

 
Methods
 

UK Biobank is a multi-site community-based study of UK residents aged 40-69 years who are registered with the National Health Service. Participants received ophthalmology examination, health questionnaire, and were asked whether they had been diagnosed with glaucoma.

 
Results
 

1919 people (1.70%) reported a glaucoma diagnosis. Mean age is 61.4 years among those with glaucoma versus 56.7 years among those without (p<0.001). Frequency among people age 40-49 is 0.48%, among those age 50-59 is 1.18% (p<0.001), and among those age 60-70 is 2.7% (p<0.001). Frequency is lower among women (1.37%) versus men (2.10%, p=0.001). When ethnicity is considered, 1.62% whites, 3.28% blacks (p<0.001 compared to whites), 2.14% Asians (p=0.009), 1.55% Chinese (p=0.91), and 1.95% mixed/other (p=0.26) have glaucoma diagnosis. Mean Townsend deprivation index is higher among those with glaucoma (-0.72) versus those without (-0.95, p=0.001). Frequency of glaucoma is highest among those with low household income and decreases as income increases (2.39% for those with <£18000, 1.79% for £18000-30999, 1.43% for £31000-51999, 1.16% for £52000-100000, and 0.92% for >£100000); however, after adjusting for age, there is no significant association between income and glaucoma except for those in the lowest category. Mean cornea-corrected IOP in the right eye is 18.9 mmHg in those with glaucoma versus 16.0 mmHg in those without (p<0.001). Mean visual acuity in right eye is LogMar 0.09 among those with glaucoma versus 0.03 among those without (p<0.001).<br /> <br /> Multivariable regression shows significant association with older age (age 40-49 reference; age 50-59, OR 2.49; age 60-69, OR 5.41, p<0.001); male gender (OR 1.50, p<0.001); black or Asian ethnicity as compared to whites (blacks, OR 2.81, p<0.001; Asians, OR 1.46, p=0.006); income <£18000 (OR 1.27, p=0.001 compared to £31000 - 51999), higher IOP (OR 1.07 per mmHg, p<0.001); and worse visual acuity (OR 1.08 per 0.1 LogMar, p<0.001).

 
Conclusions
 

In the UK Biobank cohort, 1.7% of people report glaucoma diagnosis. Glaucoma is significantly associated with older age, higher IOP, and lower visual acuity, and is higher in men, non-white people, and those with lower income.  

 
Characteristics and frequency of glaucoma.
 
Characteristics and frequency of glaucoma.
 
 
Multivariable regression of risk factors for glaucoma.
 
Multivariable regression of risk factors for glaucoma.

 
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