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Takeya Kohno, Manabu Yamamoto, Kumiko Yoshimoto, Akira Cho, Shogo Ogawa, Michiko Hirabayashi, Tomohiro Ikeda, Kunihiko Shiraki; Changes of Fundus Autofluorescence after Reduced Fluence Photodaynamic Therapy with Verteporfin in Patients with Central Serous Choroiretinopahty. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3729.
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© ARVO (1962-2015); The Authors (2016-present)
The aim of this study was to examine changes of fundus autofluorescence (FAF) during more than 2 years of follow-up after reduced fluence photodynamic therapy (RF-PDT) with verteporfin in patients with central serous chorioretinopathy (CSCR).
We retrospectively reviewed the charts of 13 eyes of 12 patients with CSCR who were treated with RF-PDT. FAF changes in 2 years or more were examined. PDT with verteporfin was performed using Visulas PDT system and the half light fluency was obtained by reducing the magnification rate for the PDT laser lens from the original 1.4 to 1.0.
The follow-up periods after RF-PDT ranged from 24 to 61 months (mean, 41.9 ± 11.8) and the number of PDT was 1 in 11 eyes and 2 in 2 eyes. The mean logarithm of the minimun angle of visual acuity was 0.18±0.05 before PDT and 0.1±0.18 on the final examination (p=0.011). After PDT, serous retinal detachment was disappeared in 10 eyes and reduced, however remained or recurred in 3 eyes. On FAF, granular hypofluoresent areas appeared in 11 eyes during 1 year of follow-up and enlarged with time. Patchy hyperfluorescent areas had been seen in 4 eyes before or after RF-PDT and then confluent hypofluorescent areas appeared around them during the follow-up. Hypofluorescent areas were not seen in the remaining 2 eyes.
The RF-PDT for CSCR improved or maintained the visual acuity for over 2 years. However, hypofluorecent areas appeared, probably due to retinal pigment epithelium loss, which developed in various degrees after RF-PDT even though resolved conditions of the retina.
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