June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Predictive value of individual and regional retinal layer thickness on visual acuity and functional outcomes in the therapy of retinal vein occlusion
Author Affiliations & Notes
  • Ana-Maria Glodan
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Sebastian M Waldstein
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Dominika Podkowinski
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Alessio Montuoro
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Wolf-Dieter Vogl
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Computational Imaging Research Lab, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
  • Roland Leitner
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Christian Simader
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Bianca S. Gerendas
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships Ana-Maria Glodan, Austrian Federal Ministry of Science, Research and Economy; National Foundation for Research, Technology and Development (F); Sebastian Waldstein, Austrian Federal Ministry of Science, Research and Economy; National Foundation for Research, Technology and Development (F); Dominika Podkowinski, Austrian Federal Ministry of Science, Research and Economy; National Foundation for Research, Technology and Development (F); Alessio Montuoro, Austrian Federal Ministry of Science, Research and Economy; National Foundation for Research, Technology and Development (F); Wolf-Dieter Vogl, Austrian Federal Ministry of Science, Research and Economy; National Foundation for Research, Technology and Development (F); Roland Leitner, Austrian Federal Ministry of Science, Research and Economy; National Foundation for Research, Technology and Development (F); Christian Simader, Austrian Federal Ministry of Science, Research and Economy; National Foundation for Research, Technology and Development (F); Bianca Gerendas, Austrian Federal Ministry of Science, Research and Economy; National Foundation for Research, Technology and Development (F); Ursula Schmidt-Erfurth, Alcon (C), Bayer (C), Boehringer Ingelheim (C), Novartis (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3738. doi:
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      Ana-Maria Glodan, Sebastian M Waldstein, Dominika Podkowinski, Alessio Montuoro, Wolf-Dieter Vogl, Roland Leitner, Christian Simader, Bianca S. Gerendas, Ursula Schmidt-Erfurth; Predictive value of individual and regional retinal layer thickness on visual acuity and functional outcomes in the therapy of retinal vein occlusion. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3738.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: The ability to predict functional outcomes and treatment response would be a breakthrough in the therapy of macular disease. Retinal thickness (RT) has been proposed already as a surrogate marker. The aim of this study was to compare individual retinal layer (RL) thickness with the best corrected visual acuity (BCVA) in patients with Branch Retinal Vein Occlusion (BRVO) and Central Retinal Vein Occlusion (CRVO) treated with ranibizumab.

Methods: 18 patients with CRVO (n=9) and BRVO (n=9) enrolled in phase III randomized multicenter trials with data available at the Vienna Reading Center were included. Spectral-domain optical coherence tomography (SD-OCT) volume scans at baseline and monthly up to month 3 were analyzed. Masked readers manually segmented each RL surface in 14,400 B-scans. Layer thickness (LT) was measured for 8 RL including retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), IS/OS junction, outer segment PR/RPE complex (OPR) and retinal pigment epithelium (RPE). Individual and combined LT were correlated with BCVA at baseline and change in BCVA.

Results: BCVA at baseline was significantly correlated with the total RT in the central mm (CMM) area (R2=0.46, p=0.004) and the thickness of the inner RL in the CMM area (IPL+INL+OPL+ONL, R2=0.50, p=0.002) as well as the total RT in the 1-3mm area (R2=0.26, p=0.043) and the thickness of the inner RL in this area (R2=0.35, p=0.016).<br /> BCVA change at month 3 was significantly correlated with change in total RT in the CMM area (R2=0.37, p=0.022) and the thickness change of the inner RL in the CMM area (IPL+INL+OPL+ONL, R2=0.36, p=0.023) as well as the change in total RT in the 1-3mm area (R2=0.47, p=0.007), the change in thickness of the inner RL in this area (R2=0.43, p=0.011) and the change in thickness of the outer RL (IS/OS junction - RPE) (R2=0.51, p=0.004). No significant correlations were detected for other layers or areas outside 3mm eccentricity from the fovea. The association between any LT and BCVA was lost beyond the baseline examination.

Conclusions: The assessment of individual layers may provide additional prognostic value for functional outcomes under therapy for patients with RVO, especially when focusing on changes in RT in the fovea and in the inner RL.

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