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Sung Pyo Park, Won Tae Yoon, Kyoung Lae Kim; Inverse relationship between blood 25-hydroxyvitamin D and age related macular degeneration.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3764.
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Inflammation had been found to play an underlying role in age related macular degeneration (AMD). Vitamin D, a circulating steroid hormone, has properties that counteract inflammation. We aimed to determine the association between the blood 25-hydroxyvitamin D and age related macular degeneration.
We selected the 25 patients of each groups. The each groups were composed by patients with wet AMD, dry AMD and without any macular degeneration. The patients were not had any cardiovascular diseases which were included in hypertension and diabetes mellitus. We excluded the patients with vitamin D supplement. We sampled the 25-hydroxyvitamin D from blood of the patients at the same day. Every patients were filled in the questionnaire which was about smoking status, height, weight, exposure time at the sunlight, wear of sunglass during outing.
The blood 25-hydroxyvitamin D was statistically lower in patients with dry and wet AMD (21.96ng/mL, 14.30ng/mL : p < 0.001, p < 0.001) which was compared the patients with no macular degeneration. (28.89ng/mL) The blood 25-hydroxyvitamin D was statistically lower in patients with wet AMD (14.30ng/mL : p < 0.001) which was compared the patients with dry AMD. (21.96ng/mL)
The blood 25-hydroxyvitamin D level was inversely associated with dry and wet AMD which was compared of the patients without any macular degeneration. Further research will be needed to reveal the biological mechanism which was about correlation of the vitamin D and AMD.
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