June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Prevalence of age-related macular degeneration in a rural southwest island of Japan: the Kumejima study
Author Affiliations & Notes
  • Ryo Obata
    Department of Ophthalmology, Univ of Tokyo School of Medicine, Tokyo, Japan
  • Tatsuya Inoue
    Department of Ophthalmology, Univ of Tokyo School of Medicine, Tokyo, Japan
  • Miho Yasuda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Yuji Oshima
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Hiroshi Sakai
    Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
  • Shoichi Sawaguchi
    Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
  • Aiko Iwase
    Tajimi Iwase Eye Clinic, Tajimi, Japan
  • Makoto Araie
    Kanto Central Hospital, Tokyo, Japan
  • Yasuo Yanagi
    Department of Ophthalmology, Univ of Tokyo School of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships Ryo Obata, None; Tatsuya Inoue, None; Miho Yasuda, None; Yuji Oshima, None; Hiroshi Sakai, None; Shoichi Sawaguchi, None; Aiko Iwase, Topcon (P); Makoto Araie, Topcon (P); Yasuo Yanagi, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3771. doi:
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      Ryo Obata, Tatsuya Inoue, Miho Yasuda, Yuji Oshima, Hiroshi Sakai, Shoichi Sawaguchi, Aiko Iwase, Makoto Araie, Yasuo Yanagi; Prevalence of age-related macular degeneration in a rural southwest island of Japan: the Kumejima study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3771.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine the prevalence of age-related macular degeneration (AMD) in a rural southwest island of Japan.

 
Methods
 

The study was a population-based, cross-sectional study conducted in 2005-2006. Of all the residents at the age of 40 or older in Kumejima island, a rural southwest island of Japan, 3762 subjects (response rate, 81.2%) underwent a detailed ocular examination. Fundus photographs using a digital retinal camera (TRC-NW7, Topcon, Tokyo, Japan) for the right eye were used for diagnosis of AMD. Wisconsin grading system was introduced to determine the crude prevalence of (1) early AMD defined as the presence of drusen with diameter of 125μm or larger or pigmentary abnormalities and (2) that of late AMD defined as the presence of neovascular AMD or geographic atrophy. Age-standardized prevalence was also estimated after direct age standardization to the world population reported by World Health Organization (WHO). Multivariate analysis was used to analyze the relationship between early or late AMD and possible risk factors such as age, gender, axial length, and history of cataract surgery.

 
Results
 

Thirty-five subjects were excluded for the lack of baseline data. Of the remaining 3561 subjects, 2651 (74.4%) had gradable photographs. They were significantly younger than those with ungradable photographs (57.6 vs. 72.5, P<0.0001). The crude prevalence of early and late AMD with 95% confidence interval were 14.3% (13.0-15.6) and 0.15% (0.00-0.30), respectively. Additionally, age-standardized prevalence were 13.3% (12.1-14.6) and 0.12% (0.00-0.24), respectively. Logistic regression analysis revealed that older age, male, shorter axial length, and history of cataract surgery (p=0.0001 to 0.03) were correlated with the presence of early AMD, and older age (p=0.020) with late AMD.

 
Conclusions
 

The prevalence of age-related macular degeneration (AMD) in a rural southwest island of Japan was estimated. Risk factors for early AMD were older age, male, shorter axial length, and history of cataract surgery,while that of late AMD was older age.  

 
Table. Prevalence of early and late AMD. Standardized to the age distribution of the world population. Values in parentheses are the 95% confidence intervals.
 
Table. Prevalence of early and late AMD. Standardized to the age distribution of the world population. Values in parentheses are the 95% confidence intervals.

 
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