June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Quality of life in patients with retinitis pigmentosa undergoing treatment with intravitreal bone marrow-derived stem cells (Reticell -clinical trial)
Author Affiliations & Notes
  • Rubens C Siqueira
    Retina, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil
  • Andre Messias
    Retina, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil
  • Katharina Messias
    Retina, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil
  • Rafael Arcieri
    Retina, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil
  • Milton A Ruiz
    Department of bone marrow transplantation-, Beneficencia Portuguesa Hospital, Sao Jose do Rio Preto, Brazil
  • Neiglene F Souza
    Psychology, CERV, Sao Jose do Rio Preto, Brazil
  • Lia C Martins
    Biology, Paulista University (UNIP), Sao Jose do Rio Preto, Brazil
  • Rodrigo Jorge
    Retina, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil
  • Footnotes
    Commercial Relationships Rubens Siqueira, None; Andre Messias, None; Katharina Messias, None; Rafael Arcieri, None; Milton Ruiz, None; Neiglene Souza, None; Lia Martins, None; Rodrigo Jorge, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3812. doi:
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      Rubens C Siqueira, Andre Messias, Katharina Messias, Rafael Arcieri, Milton A Ruiz, Neiglene F Souza, Lia C Martins, Rodrigo Jorge; Quality of life in patients with retinitis pigmentosa undergoing treatment with intravitreal bone marrow-derived stem cells (Reticell -clinical trial). Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3812.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To assess the vision-related quality of life in patients with retinitis pigmentosa (RP) undergoing treatment with intravitreal use of autologous bone marrow-derived stem cells .

Methods: The study included 20 patients with RP undergoing treatment with intravitreal autologous bone marrow-derived stem cells . We evaluate the vision-related quality of life (VRQOL) of patients using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). Patients were scheduled to answer the questionnaire before treatment and 3 and 12 months after treatment.

Results: All patients completed the survey as scheduled.<br /> There was a statistically significant improvement (p <0.05) in the quality of life of patients 3 months after treatment, whereas by the 12th month there was no statistically significant difference from baseline.

Conclusions: Cell therapy with intravitreal use of bone marrow-derived stem cells can improve the quality of life of patients with RP, although the improvement is lost with time. A larger number of cases will be necessary to evaluate the repercussions of this therapy on the quality of life of these patients.

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