June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Imaging of optic disc drusen: Swept-Source (SS)-OCT versus B-scan ultrasound
Author Affiliations & Notes
  • Michelle Ahn
    University of Pittsburgh School of Medicine, Pittsburgh, PA
  • Andrew W Eller
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • Bo Wang
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • Ellen Mitchell
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • Joel S Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • Chen D Lu
    Department of Electrical Engineering and Computer Science, and Research Laboratory for Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • Ireneusz Grulkowski
    Department of Electrical Engineering and Computer Science, and Research Laboratory for Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • James G Fujimoto
    Department of Electrical Engineering and Computer Science, and Research Laboratory for Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • Gadi Wollstein
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • Gabrielle Rachelle Bonhomme
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • Footnotes
    Commercial Relationships Michelle Ahn, None; Andrew Eller, None; Bo Wang, None; Ellen Mitchell, None; Joel Schuman, Zeiss (P); Chen Lu, None; Ireneusz Grulkowski, None; James Fujimoto, Optovue (I), Zeiss (P); Gadi Wollstein, None; Gabrielle Bonhomme, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3872. doi:
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    • Get Citation

      Michelle Ahn, Andrew W Eller, Bo Wang, Ellen Mitchell, Joel S Schuman, Chen D Lu, Ireneusz Grulkowski, James G Fujimoto, Gadi Wollstein, Gabrielle Rachelle Bonhomme; Imaging of optic disc drusen: Swept-Source (SS)-OCT versus B-scan ultrasound. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3872.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Optic disc drusen are currently diagnosed by B-scan ultrasonography, but this modality is difficult to maneuver, uncomfortable to patients, and operator-dependent. The aim of this prospective study was to determine whether an alternative imaging technology, the Swept-Source (SS)-OCT, improves the ability to identify optic disc drusen compared to the gold standard of B-scan ultrasonography.

Methods: We recruited patients who were of 5 years of age or more and diagnosed with anomalous optic nerve heads. Subjects received a complete ophthalmologic exam of the anterior and posterior segments as well as a B-scan ultrasound and SS-OCT. The prototype SS-OCT system was operated at 1060nm wavelength with 100kHz axial scan rate. Images from each of the two imaging technologies were then independently and qualitatively assessed for the presence and visibility of drusen.

Results: A total of 13 patients (4 males and 9 females) were recruited. The average age was 47.6 years. Among these subjects, there were 21 eyes with optic disc drusen. Drusen were confirmed in B-scans by hyper-reflectance of the calcium deposits at low gain. In the SS-OCT, they were hypo-reflective bodies that could be visualized in a 3D cube, making it possible to also pinpoint their locations. Optic disc drusen were identifiable through SS-OCT in all 21 eyes (100%), had well-demarcated borders in 19 (90.5%), and were seen along their entire depths in 16 (76.2%).

Conclusions: While the B-scan tests for the hyper-reflective properties of the calcified bodies, the SS-OCT allows anatomic visualization of the actual deposits. Here, we were able to identify optic disc drusen in all of the eyes that were diagnosed with this condition through B-scan. The SS-OCT therefore has equal ability to detect drusen compared to B-scan ultrasonography, and the additional benefits of ease of conducting the exam, patient comfort, data standardization, and potential quantification of drusen size make it more clinically useful.

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