June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Characteristics of microcystic macular edema determined by adaptive optics scanning laser ophthalmoscopy (AO-SLO) in eyes with optic neuropathy
Author Affiliations & Notes
  • Takao Endo
    Department of Ophthalmology, Osaka Univ Grad School of Med, Suita, Japan
  • Takashi Fujikado
    Applied Visual Science, Osaka Univ Grad School of Med, Osaka, Japan
  • Masakazu Hirota
    Applied Visual Science, Osaka Univ Grad School of Med, Osaka, Japan
  • Hiroyuki Kanda
    Applied Visual Science, Osaka Univ Grad School of Med, Osaka, Japan
  • Takeshi Morimoto
    Applied Visual Science, Osaka Univ Grad School of Med, Osaka, Japan
  • Shinichi Usui
    Department of Ophthalmology, Osaka Univ Grad School of Med, Suita, Japan
  • Kohji Nishida
    Department of Ophthalmology, Osaka Univ Grad School of Med, Suita, Japan
  • Footnotes
    Commercial Relationships Takao Endo, None; Takashi Fujikado, None; Masakazu Hirota, None; Hiroyuki Kanda, None; Takeshi Morimoto, None; Shinichi Usui, None; Kohji Nishida, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3876. doi:
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      Takao Endo, Takashi Fujikado, Masakazu Hirota, Hiroyuki Kanda, Takeshi Morimoto, Shinichi Usui, Kohji Nishida; Characteristics of microcystic macular edema determined by adaptive optics scanning laser ophthalmoscopy (AO-SLO) in eyes with optic neuropathy. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3876.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Microcystic macular edema (MME) is detected as an arcuate-shaped low reflectance area in the macula in the infrared fundus photographs and in the adaptive optics scanning laser ophthalmoscopic (AO-SLO) images. The low reflectance area corresponds to the area of microcystic changes in the inner nuclear layer (INL) detected by optical coherence tomography (OCT), and they have been reported in a variety of optic nerve diseases. The purpose of this study was to determine whether MME was present in eyes with optic neuropathy and to determine their characteristics.

Methods: This was a retrospective study of 41 eyes of 25 patients with optic neuropathy or glaucoma. There were 7 eyes with traumatic optic neuropathy, 3 eyes with ischemic optic neuropathy, 4 eyes with ethambutol optic neuropathy, 4 eyes with Leber’s optic neuropathy, 5 eyes with optic neuritis, 6 eyes with optic nerve atrophy and 12 eyes with glaucoma. All of the patients were examined by AO-SLO and OCT at the Osaka University Hospital between August 2013 and October 2014. The visual acuity and incidence of MME were determined in these patients.

Results: Low-reflectance areas in the AO-SLO image with microcysts in the OCT images were observed in 11 eyes (26.8%). The visual acuity was significantly poorer in eyes with MME (1.9±1.2 logMAR units) than in eyes without MME (0.42±0.73 log units; P<0.0). Eight of the 11 eyes with MME had arcuate low reflectance area but 3 eyes with glaucoma had a nerve fiber layer defect (NFLD)-like low reflectance area by AO-SLO. This NFLD-like low reflectance area did not correspond to the scotoma in the Humphery visual fields, which were different from the ordinal NFLD.

Conclusions: The presence of MME may be related to an advanced stage of optic neuropathy. The shape of the MME in the AO-SLO images is not only arcuate but can also be NFLD-like.

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