June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Investigating the Development of Pseudodrusen in Age-related Macular Degeneration
Author Affiliations & Notes
  • Ferdinand Georg Schlanitz
    Ophthalmology, Medical University Vienna, Vienna, Austria
  • Magdalena Baratsits
    Ophthalmology, Medical University Vienna, Vienna, Austria
  • Katharina Eibenberger
    Ophthalmology, Medical University Vienna, Vienna, Austria
  • Alessio Montuoro
    Ophthalmology, Medical University Vienna, Vienna, Austria
  • Stefan Zotter
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Bernhard Baumann
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Michael Pircher
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Christoph K Hitzenberger
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Ophthalmology, Medical University Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships Ferdinand Schlanitz, None; Magdalena Baratsits, None; Katharina Eibenberger, None; Alessio Montuoro, None; Stefan Zotter, Canon (F); Bernhard Baumann, Canon (F); Michael Pircher, Canon (C), Canon (F); Christoph Hitzenberger, Canon (F); Ursula Schmidt-Erfurth, Alcon (F), Bayer (F), Boehringer (F), Novartis (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3957. doi:
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      Ferdinand Georg Schlanitz, Magdalena Baratsits, Katharina Eibenberger, Alessio Montuoro, Stefan Zotter, Bernhard Baumann, Michael Pircher, Christoph K Hitzenberger, Ursula Schmidt-Erfurth; Investigating the Development of Pseudodrusen in Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3957.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: The aim of this study was to investigate the development of pseudodrusen (PD) in age-related macular degeneration (AMD) longitudinally by three-dimensional segmentation of polarization-sensitive OCT (PS-OCT) volume scans.

Methods: 109 patients with early AMD were scanned using a wide-field PS-OCT (scanning area 30°x30°, volume scan 1024x250) in a regular follow-up scheme for at least one year. The collective was reviewed and patients with PD were selected for grading. The RPE and drusen were segmented by PS-OCT automatically. Two expert graders segmented manually every PD in the volume scan at baseline and at the one-year follow-up visit. Every hyperreflective matrial above the retinal pigment epithelium (RPE) and below the external limiting membrane (ELM) layer was defined as PD.

Results: 14 eyes with PD were segmented manually by the graders. PD did not show distinct borders and therefore differentiating between single entities was difficult. The mean volume at baseline was 0.21 mm3 and at year one 0.27 mm3. At the same time, the drusen volume increased in most eyes. However, in some eyes, spontaneous drusen regression was observed, without correlation to the development of PD at the same time.

Conclusions: Due to the RPE-sensitivity of the PS-OCT, pseudodrusen could be segmented in a more reliable way than in regular SD-OCT scans. By grading the hyperreflective structures located above RPE, a plaque-like deposition was found, as described by histologic investigations. PD did show a steady increase in their volume, and interestingly, their development appeared to be independent from that of classic drusen, and was not affected by a spontaneous regression of the latter.

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