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Sujin Hoshi, Fumiki Okamoto, Yoshimi Sugiura, Genichiro Kishino, Tomoya Murakami, Mikki Arai, Tatsuo Hirose, Tetsuro Oshika; Sealing retinal breaks with FocalSeal® in experimental rhegmatogenous retinal detachment in rabbit eyes. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):397.
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© ARVO (1962-2015); The Authors (2016-present)
FocalSeal® is an absorbable polyethylene glycol-based synthetic hydrogel sealant. This liquid is polymerized under visible xenon illumination, and forms clear, flexible, and firmly adherent hydrogel. This study was conducted to examine the effect of FocalSeal® for sealing retinal breaks in experimental rhegmatogenous retinal detachment in rabbit eyes.
Experimental retinal detachment with a break was made during a 25-gauge vitrectomy in six rabbit eyes. After performing fluid-air exchange, FocalSeal® was applied to entirely cover iatrogenic retinal breaks, and was polymerized with a 60-second application of xenon light in three rabbit eyes (FS group). Air-fluid exchange was then performed, and operations were finished without intraocular tamponade. In other three eyes, the same procedures were performed without FocalSeal® application (control group). Funduscopic examination and optical coherence tomography (OCT) was carried out in both groups at 1 and 7 days, and 1 and 3 months postoperatively.
The funduscopic examination showed that the retina was reattached in all eyes of the FS group. Meanwhile all three eyes of the control group resulted in proliferative vitreoretinopathy. FocalSeal® was observed on the retinal breaks at 1 and 7 days, but was not observed after 1 month postoperatively.
In our study, FocalSeal® successfully sealed retinal breaks, and repaired experimental rhegmatogenous retinal detachment without intraocular tamponade. FocalSeal® was found to be beneficial to seal retinal breaks during and after vitrectomy for rhegmatogenous retinal detachment.
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