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Pedro Mario González, Alejandro Fernando Ibarra-Lozano, Jorge E Valdez, Jaime Torres; Pseudomonas aeruginosa Ocular Strains Resistant to Ceftazidime in Northeast of Mexico. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4049.
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The purpose of this case series is to report Pseudomonas aeruginosa resistance to ceftazidime in keratitis isolates in northeast of Mexico. Concern exists around the growing antibiotic resistance in different ocular pathogens worldwide. Ceftazidime is known to be one of the antimicrobial agents used with a high sensitivity profile in bacterial keratitis caused by Pseudomonas aeruginosa.
Patient records from January 2010 to November of 2014 were revised. Twenty eight patients were found with the diagnosis of infectious keratitis. Eight cases were culture positive for Pseudomona aeruginosa. variables studied included: gender, age, time of presentation to consultation, visual acuity, comorbidities, antibiotic sensitivity/resistance pattern and complications encountered.
Eight culture positive P. aeruginosa cases were found between 2010 to the end of 2014. There were 2 females and 6 males, the age range was from 19 to 67 years old. Ceftazidime resistance was reported in seven cases. Susceptibility was reported for ciprofloxacin, meropenem, amikacin and gentamicin. Ciprofloxaxin and meropenem were the ones with the lowest minimal inhibitory concentration. Final visual acuity had a strong relation with the initially reported. Two cases were associated to traumatism and one to soft contact lenses use. Two cases had corneal perforation.
This study reviews a series of cases of P. aeruginosa keratitis in northeast of Mexico; the microbiologic profile showed 87.5% resistance to ceftazidime. Sensitivity to meropenem, ciprofloxacin, amikacin and gentamicin was of 100%. This data should influence the management of this entity in the geographic zone examined.
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