June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Automated Photosensitivity Assessment in Achromatopsic and Healthy Subjects
Author Affiliations & Notes
  • Mariela C Aguilar
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Alex Gonzalez
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Cornelis J Rowaan
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Potyra R Rosa
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Karam Alawa
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Byron L Lam
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
    Brien Holden Vision Institute, UNSW, Sydney, NSW, Australia
  • Footnotes
    Commercial Relationships Mariela Aguilar, None; Alex Gonzalez, None; Cornelis Rowaan, None; Potyra Rosa, None; Karam Alawa, None; Byron Lam, None; Jean-Marie Parel, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4313. doi:
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    • Get Citation

      Mariela C Aguilar, Alex Gonzalez, Cornelis J Rowaan, Potyra R Rosa, Karam Alawa, Byron L Lam, Jean-Marie A Parel; Automated Photosensitivity Assessment in Achromatopsic and Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4313.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To assess and compare the photosensitivity discomfort threshold in Achromatopsic and healthy subjects using the 2nd Generation BPEI Photosensitivity Tester.

 
Methods
 

The 1st Generation instrument (Aguilar MC et al, IOVS. 2014; 55: E-Abstract 4108 and Alawa K, IOVS. 2014; 55: E-Abstract 4109) was modified to comprise a bi-cupola concave light array panel with 210 white LED’s that are either manually controlled with a knob or computer controlled. The light intensity ranges from 1-32,000 lux at 50 cm. The instrument has two testing modes; one for subjects with normal light tolerance, the other has an enhanced mode for subjects having low light tolerance. The audio prerecorded testing instructions can be provided in four languages (English, Spanish, French, and Portuguese). The automated instrument varies the intensity of the light stimuli and the subject is instructed in their preferred language to indicate if it is uncomfortable by pressing a hand-held button. The testing is complete after 10 response reversals, from which a predicted photosensitivity threshold is calculated.<br /> <br /> Thus far, seven Achromatopsic subjects (5 females and 2 males, age = 14.3±6.0) and eleven healthy subjects (5 females and 6 males, age = 31.9±8.5) were tested under an IRB approved protocol. Prior to testing, the subjects rested during a 5 min. adaptation period in the examination room illuminated with 4 lux. Ambient conditions are monitored utilizing: humidity, temperature, and lux meters.

 
Results
 

Seven Achromatopsic subjects were found to have a mean predicted photosensitivity threshold of 0.75±0.66 log(lux). Eleven healthy subjects were found to have a mean predicted photosensitivity threshold of 3.32±0.66 log(lux). A one-way analysis of variance was performed and there is a statistically significant difference (p<0.0001) in the threshold of photosensitivity experienced between the Achromatopsic and healthy subject groups.

 
Conclusions
 

The autonomous 2nd Generation BPEI Photosensitivity Tester can assess a wide range of photosensitivity thresholds by detecting, quantifying, and recording the individual differences in sensory capabilities. Ongoing studies are being conducted in order to better understand the wide range of photosensitivity thresholds.  

 
Figure. 2nd Generation BPEI Photosensitivity Tester
 
Figure. 2nd Generation BPEI Photosensitivity Tester

 
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