June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
The effects of 3% diquasfol ophthalmic solution on tear MUC5AC concentrations in normal and experimental dry eye rat model
Author Affiliations & Notes
  • Kwang-Eon Choi
    Ophthalmology, Korea university Guro hospital, Seoul, Korea (the Republic of)
  • Su Yeon Kang
    Ophthalmology, Korea university Guro hospital, Seoul, Korea (the Republic of)
  • Jay Won Rhim
    Ophthalmology, Korea university Guro hospital, Seoul, Korea (the Republic of)
  • Hyo Myung Kim
    Ophthalmology, Korea university Guro hospital, Seoul, Korea (the Republic of)
  • Jong Suk Song
    Ophthalmology, Korea university Guro hospital, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships Kwang-Eon Choi, None; Su Yeon Kang, None; Jay Won Rhim, None; Hyo Myung Kim, None; Jong Suk Song, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4424. doi:
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      Kwang-Eon Choi, Su Yeon Kang, Jay Won Rhim, Hyo Myung Kim, Jong Suk Song, ; The effects of 3% diquasfol ophthalmic solution on tear MUC5AC concentrations in normal and experimental dry eye rat model. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4424.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: The aim of this study is to evaluate the effect of diquasfol ophthalmic solution on tear MUC5AC concentrations in normal and experimental dry eye rat model.

Methods: In the first study, tear MUC5AC concentrations were measured at 5, 10, 15, and 20 minutes after instillation of diquasfol ophthalmic solution, and the change of tear MUC5AC level was evaluated. In the second study, tear MUC5AC concentrations were measured in both control and dry eye rat models. To make dry eye rat models, male Lewis rats were subcutaneously injected with scopolamine hydrobromide and placed in a controlled environment chamber with low humidity for 3 days. Control rats received no intervention. The effects of diquasfol ophthalmic solution on tear MUC5AC concentrations were compared between normal and dry eye rat models.

Results: In the first study, tear MUC5AC concentrations were increased from 5 minutes to 20 minutes after instillation of diquasfol ophthalmic solution, compared with control eyes. Although the tear MUC5AC concentrations were the highest at 15 minutes after instillation, MUC5AC levels were significantly higher at each time point compared with control eyes. In the second study, tear MUC5AC levels were significantly lower in dry eye rat models than in normal controls (12.4±0.25 ug/ml, 15.5±1.75ug/ml, respectively). However, topical instillation of diquasfol ophthalmic solution increased tear MUC5AC levels in normal controls as well as in dry eye rat models.

Conclusions: Topical diquasfol ophthalmic solution increased tear MUC5AC concentrations from 5 minutes up to 20 minutes after instillation in normal rat eyes. This effect was also found in dry eye rat models.

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