June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Incomplete response to artificial tears is associated with self-reported features of neuropathic ocular pain
Author Affiliations & Notes
  • Hatim Batawi
    Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL
  • Roy Levitt
    Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL
    Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL
  • Elizabeth Felix
    Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL
    Department of Physical Medicine and Rehabilitation, University of Miami Miller School of Medicine, Miami, FL
  • Todd P Margolis
    Ophthalmology, Washington University School of Medicine, St Louis, MO
  • Constantine Sarantopoulos
    Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL
    Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL
  • Eden R Martin
    John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL
    John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL
  • Anat Galor
    Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL
  • Footnotes
    Commercial Relationships Hatim Batawi, None; Roy Levitt, None; Elizabeth Felix, None; Todd Margolis, None; Constantine Sarantopoulos, None; Eden Martin, None; Anat Galor, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4445. doi:
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    • Get Citation

      Hatim Batawi, Roy Levitt, Elizabeth Felix, Todd P Margolis, Constantine Sarantopoulos, Eden R Martin, Anat Galor; Incomplete response to artificial tears is associated with self-reported features of neuropathic ocular pain. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4445.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Artificial tears are first-line therapy for patients with dry eye symptoms. It is not known, however, which patients will respond to therapy. The purpose of this study was to evaluate whether certain features of dry eye were more frequent in those reporting an incomplete therapeutic response to artificial tears

Methods: Cross-sectional study of 71 individuals reporting artificial tear use (hypromellose 0.4%), at least in part, to treat dry eye associated ocular pain. An evaluation was performed to assess dry eye symptoms, as well as ocular and non-ocular pain complaints. The main outcome measures were factors associated with an incomplete response to artificial tears.

Results: By self-report, 14 patients reported no improvement, 38 partial improvement, and 19 complete improvement in ocular pain with artificial tears. Dry eye severity impacted treatment response as those with more severe symptoms were less likely to report complete improvement with artificial tears. A similar pattern was seen with respect to self-reported ocular and non-ocular pain. Patients reporting symptoms consistent with NOP including hot-burning ocular pain and/or hypersensitivity to wind were also less likely to report complete improvement with artificial tears compared to those without these complaints. In a multivariable model, hot burning ocular pain (odds ratio (OR) 0.27, 95% confidence interval (CI) 0.07-0.95, p=0.04) and a higher non-ocular pain score (OR 0.73, 95% CI 0.58-0.93, p=0.01), were significantly associated with incomplete response to artificial tears.

Conclusions: Patients who reported an incomplete response to artificial tears more frequently endorsed symptoms of NOP and more severe ocular and non-ocular pain compared to those who reported complete response to therapy.

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