June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Lipid tear turnover in meibomian gland dysfunction: an optical coherence tomography study
Author Affiliations & Notes
  • Maurizio Fossarello
    Ophthalmology, Azienda Ospedaliero Universitaria Cagliari, Cagliari, Italy
  • Franco Coronella
    Ophthalmology, Azienda Ospedaliero Universitaria Cagliari, Cagliari, Italy
  • Giovanni Maria Satta
    Ophthalmology, Azienda Ospedaliero Universitaria Cagliari, Cagliari, Italy
  • Pietro Emanuele Napoli
    Ophthalmology, Azienda Ospedaliero Universitaria Cagliari, Cagliari, Italy
  • Footnotes
    Commercial Relationships Maurizio Fossarello, None; Franco Coronella, None; Giovanni Satta, None; Pietro Napoli, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4456. doi:
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      Maurizio Fossarello, Franco Coronella, Giovanni Maria Satta, Pietro Emanuele Napoli; Lipid tear turnover in meibomian gland dysfunction: an optical coherence tomography study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4456.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To assess by means of optical coherence tomography (OCT) the turnover of tear lipids in patients with meibomian gland disease (MGD) and its correlation with classical tear tests.

Methods: Forty-two adult patients with MGD were evaluated for abnormalities of ocular surface in the same sequence. It included clinical history, a symptom questionnaire (OSDI = Ocular Surface Disease Index), fluorescein tear break-up time (FTBUT), fluorescein staining of the cornea and conjunctiva graded according to the Oxford system (FSOS), standardized visual scale (SVST), Schirmer I test, and a slit lamp examination of the lid margins and meibomian glands. A novel technique of contrast-enhanced OCT imaging was used to determine the clearance of tear lipids (CoL).

Results: The correlations between CoL and OSDI, FTBUT, FSOS, Schirmer test scores, were found to be statistically significant (p<0.001, Spearman correlation coefficient was 0.82, -0.79, 0.64, -0.5 -0.49, respectively). Moreover, also a significant relationship between CoL and the aqueous tear clearance (SVST) was observed (Spearman correlation coefficient was 0.82, p<0.001).

Conclusions: The reduced dynamics of tear lipids was associated with the MGD. This new finding could lead to a better understanding of the alterations and of the complex pathogenesis of dry eye syndrome.

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