June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Determinants of ocular symptoms in postmenopaual women with dry eye.
Author Affiliations & Notes
  • Fiona Stapleton
    School of Optometry and Vision Science, University of New South Wales, Kensington Sydney, NSW, Australia
  • Noor Badarudin
    School of Optometry and Vision Science, University of New South Wales, Kensington Sydney, NSW, Australia
  • Jing Jing You
    Save Sight Institute, University of Sydney, Sydney, NSW, Australia
  • Ulrike Hampel
    School of Optometry and Vision Science, University of New South Wales, Kensington Sydney, NSW, Australia
  • John Eden
    Sydney Menopause Centre, Royal Hospital for Women, Randwick, NSW, Australia
    Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
  • Leanne Raisin
    School of Optometry and Vision Science, University of New South Wales, Kensington Sydney, NSW, Australia
  • Jennifer Williams
    School of Optometry and Vision Science, University of New South Wales, Kensington Sydney, NSW, Australia
  • Cecilia Chao
    School of Optometry and Vision Science, University of New South Wales, Kensington Sydney, NSW, Australia
  • Blanka Golebiowski
    School of Optometry and Vision Science, University of New South Wales, Kensington Sydney, NSW, Australia
  • Footnotes
    Commercial Relationships Fiona Stapleton, None; Noor Badarudin, None; Jing Jing You, None; Ulrike Hampel, None; John Eden, None; Leanne Raisin, None; Jennifer Williams, None; Cecilia Chao, None; Blanka Golebiowski, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4473. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Fiona Stapleton, Noor Badarudin, Jing Jing You, Ulrike Hampel, John Eden, Leanne Raisin, Jennifer Williams, Cecilia Chao, Blanka Golebiowski; Determinants of ocular symptoms in postmenopaual women with dry eye.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4473.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: Dry eye in women is more prevalent postmenopause and alterations in sex hormone levels may be implicated. This study explored the relationship between serum concentration of sex hormones and dry eye symptoms and ocular surface signs.

Methods: The study involved 46 postmenopausal women diagnosed with non-Sjögrens dry eye and not taking hormone replacement therapy (mean age 64±5 years, 14±6 years since menopause). The following measurements were conducted at a single timepoint: Ocular symptoms (Ocular Surface Disease Index (OSDI) and Ocular Comfort Index (OCI)), tear function (non-invasive tear break-up time (NITBUT), tear osmolarity (TearLab), tear volume (Phenol Red Thread and Schirmer tests)), ocular surface staining and meibomian gland assessment using grading scales, ocular surface sensitivity (Cochet-Bonnet aesthesiometer) and venous blood collection. Serum concentrations of 17β-estradiol (E2), 3α-diol-G, DHEA-S and their ratios were determined using Enzyme-linked immunosorbent assay (ELISA). Univariate associations were examined using Spearman’s correlations and multiple linear regression analysis was subsequently used to examine predictors of dry eye symptoms.

Results: Mean serum concentration of E2 was 10.8±19.7pg/ml, 2.10±2.77ng/ml of 3α-diol-G and 0.73±0.55μg/ml of DHEA-S. Mean symptoms scores were 27.0±18.1 (OSDI) and 40.3±8.4 (OCI). Only tear osmolarity and meibomian gland secretion quality were significant predictors in the OSDI model; this model explained 20% of the variance in the OSDI score (F(6, 39)=2.858, p=0.02, R2adj= 0.20). Eyelid vascularity and meibomian gland expressibility were significant predictors in the OCI dryness frequency model, explaining 29% of the variance in dryness frequency (F(6, 39)=4.015, p=0.003, R2adj=0.29). Although serum hormones were associated with symptoms scores on univariate correlations, E2, 3α-diol-G, DHEA-S or their ratios were not found to be significant predictors of ocular symptoms in the full multivariate model(p>0.05).

Conclusions: Meibomian gland and lid variables are significant predictors of ocular symptoms in postmenopausal women with dry eye, but serum hormone levels were not shown to play a significant role in this study. These findings would suggest that meibomian gland disease underpins dry eye symptoms in this cohort and examination in a lager cohort is required may further elucidate the role of sex hormones in non-Sjögrens dry eye in postmenopausal women.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×