June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Lacrimal gland morphostructural analysis by MR imaging: interobserver, age and gender variations
Author Affiliations & Notes
  • Denny Marcos Garcia
    Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, Ribeirao Preto, Brazil
    Core of Research in Ocular Physiopathology and Therapeutics (NAP-FTO), Ribeirao Preto Medical School - USP, Ribeirão Preto, Brazil
  • Pedro Sant'Anna
    Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, Ribeirao Preto, Brazil
    Core of Research in Ocular Physiopathology and Therapeutics (NAP-FTO), Ribeirao Preto Medical School - USP, Ribeirão Preto, Brazil
  • Alex Vasconcelos
    Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, Ribeirao Preto, Brazil
    Core of Research in Ocular Physiopathology and Therapeutics (NAP-FTO), Ribeirao Preto Medical School - USP, Ribeirão Preto, Brazil
  • Luciana Oharomari
    Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, Ribeirao Preto, Brazil
  • Marcelo Caram Ribeiro Fernandes
    Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, Ribeirao Preto, Brazil
  • Valdair Francisco Muglia
    Division of Imaging, Department of Internal Medicine,, Ribeirao Preto Medical School, Ribeirão Preto, Brazil
    Core of Research in Ocular Physiopathology and Therapeutics (NAP-FTO), Ribeirao Preto Medical School - USP, Ribeirão Preto, Brazil
  • Eduardo M Rocha
    Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, Ribeirao Preto, Brazil
    Core of Research in Ocular Physiopathology and Therapeutics (NAP-FTO), Ribeirao Preto Medical School - USP, Ribeirão Preto, Brazil
  • Footnotes
    Commercial Relationships Denny Garcia, None; Pedro Sant'Anna, None; Alex Vasconcelos, None; Luciana Oharomari, None; Marcelo Fernandes, None; Valdair Muglia, None; Eduardo Rocha, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4476. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Denny Marcos Garcia, Pedro Sant'Anna, Alex Vasconcelos, Luciana Oharomari, Marcelo Caram Ribeiro Fernandes, Valdair Francisco Muglia, Eduardo M Rocha; Lacrimal gland morphostructural analysis by MR imaging: interobserver, age and gender variations. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4476.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: The aim of the study is to identify morphostructural changes of lacrimal glands (LG) related to age and gender using Magnetic Resonance Imaging (MR).

Methods: LG images of 26 patients submitted to 3.0 Tesla MR scanner were retrospectively evaluated by 02 observers using OsiriX (Black Duck Software Inc, Burlington, MA, USA) or Image J (NIH, Bethesda, MD, USA). The area in the largest section, volume and the density of the right and left LG were obtained and submitted to analysis of agreement among observers and correlation tests with the age and the gender of the patients (JMP® 10.0 software, SAS Institute Inc., Cary, NC, USA).

Results: The mean age was 56.9 ± 16.2 years and gender ratio was 0.73 F: 1M. The findings indicate that the axial LG area in the largest section is 65.2 ± 33.5 mm2 , volume is 537.4 ± 310.1 mm3 and density is 175.1 ± 65.1 units using 3.0 Tesla MNR. There was no significant correlation with age (p>0.05 for the three parameters). Right LG was significantly bigger for area (p = 0.002), volume (p = 0.001) but not for density (p = 0.08), compared to left LG. The interobserver variability was 42% and intraclass correlation coefficient was 0.329.

Conclusions: the present work indicates the normal features of LG under 3.0 Tesla MR imaging. Standardization in LG measures is required since the interobserver agreement was poor. In the future it may contribute for improving understanding of pathophysiology of LG dysfunction and dry eye disease.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×