June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Ganglion Cell Complex Assessed by Spectral-Domain Optical Coherence Tomography in Normal Older Adults from the City of Parintins, Brazilian Amazon Region
Author Affiliations & Notes
  • Paula Y Sacai
    Departamento de Oftalmologia e Ciencias Visuais, Universidade Federal de São Paulo, Sao Paulo, Brazil
  • Nivea Nunes Cavascan
    Departamento de Oftalmologia e Ciencias Visuais, Universidade Federal de São Paulo, Sao Paulo, Brazil
  • Sung Eun Song Watanabe
    Departamento de Oftalmologia e Ciencias Visuais, Universidade Federal de São Paulo, Sao Paulo, Brazil
  • Marcela Cypel
    Departamento de Oftalmologia e Ciencias Visuais, Universidade Federal de São Paulo, Sao Paulo, Brazil
  • Sergio Munoz
    Departamento de Salud Publica, Universidad de La Frontera, Temuco, Chile
  • Marcos Jacob Cohen
    Instituto de Olhos de Manaus, Manaus, Brazil
  • Jacob Moyses Cohen
    Departamento de Cirurgia, Setor de Oftalmologia, Universidade Federal do Amazonas, Manaus, Brazil
  • Adriana Berezovsky
    Departamento de Oftalmologia e Ciencias Visuais, Universidade Federal de São Paulo, Sao Paulo, Brazil
  • Rubens Belfort Jr
    Departamento de Oftalmologia e Ciencias Visuais, Universidade Federal de São Paulo, Sao Paulo, Brazil
  • Solange Rios Salomao
    Departamento de Oftalmologia e Ciencias Visuais, Universidade Federal de São Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships Paula Sacai, None; Nivea Cavascan, None; Sung Watanabe, None; Marcela Cypel, None; Sergio Munoz, None; Marcos Cohen, None; Jacob Cohen, None; Adriana Berezovsky, None; Rubens Belfort Jr, None; Solange Salomao, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4537. doi:
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      Paula Y Sacai, Nivea Nunes Cavascan, Sung Eun Song Watanabe, Marcela Cypel, Sergio Munoz, Marcos Jacob Cohen, Jacob Moyses Cohen, Adriana Berezovsky, Rubens Belfort Jr, Solange Rios Salomao; Ganglion Cell Complex Assessed by Spectral-Domain Optical Coherence Tomography in Normal Older Adults from the City of Parintins, Brazilian Amazon Region. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4537.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To provide normative values of ganglion cell complex (GCC) and its possible associations with retinal nerve fiber layer (RNFL) thickness in a subset of participants of a population-based ocular eye survey using spectral-domain optical coherence tomography (SD-OCT).

Methods: The Brazilian Amazon Region Eye Survey (BARES) is an ongoing population-based prevalence study of visual impairment, blindness and ocular diseases in adults aged 45 years and older from urban and rural areas of Parintins city, Brazil. GCC and RNFL measurements were obtained through dilated pupils using iVue-100 SD-OCT in a subset of participants with presenting distance visual acuity≥20/32, normal eye exam and absence of previous ocular surgery. CCG and RNFL thickness (µm) was measured overall and also for superior (SH) and inferior hemispheres (IH). Data from one randomly-chosen eye of each participant were analyzed and a multiple linear regression model was performed to investigate the effects of age, gender and cup-to-disc area ratio on CCG. Pearson’s correlation was used to compare GCC with RNFL parameters.

Results: Out of 1180 participants, 64 (36 females) were eligible for this study. Age ranged from 45 to 65 years (mean=52±5 years). Considering GCC parameters, overall, SH and IH thickness were respectively 94.42±9.25µm, 95.98±8.22µm and 94.79±7.78µm. The mean overall RNFL thickness was 104.16±9.15µm, with thickest RNFL in the SH (107.03±10.55µm), followed by the IH (104.36±10.81µm). Pearson correlation showed moderate and significant association (p<0.001) between GCC and RNFL for overall (r=0.588), SH (r=0.542) and IH (r=0.537). There were no significant correlations of GCC thickness with gender, age and cup-to-disc area ratio.

Conclusions: The current results provided a normative database of ganglion cell complex parameters as well as its association with retinal nerve fiber layer in this cohort. These data might be useful for glaucoma diagnosis and progression monitoring in this population.

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