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Sebastiao Cronemberger, Rafael Vidal Mérula, Nassim S Calixto, Erica A de Abreu Borges; Effects of age, gender, race, biometric parameters and refractive error on retinal nerve fiber layer of acute primary angle closure and fellow eyes. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4569.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the influences of age, gender, race, biometric parameters and refractive error on RNFL using SD-OCT in acute primary angle closure (APAC) and fellow eyes.
In a cross-sectional comparative study subjects 18 years of age or older with APAC attended at the Glaucoma Service of São Geraldo Hospital were recruited. These patients were identified from the hospital computerized database. All patients underwent an ophthalmic examination, including a RNFL imaging using spectral-domain optical coherence tomography (SD-OCT), ultrasound biometric assessment, and automated perimetry by means of Interzeag Octopus 1-2-3 (Haag-Streit AG, Koeniz, Switzerland). APAC eyes will compared with the fellow eyes as controls.
Ten patients who had the APAC acute crisis were enrolled in this study. They had the following profile, mean age of 63.9 (±9.2) years, 80% women, 60% leukodermic, 100% bilateral iridectomy, average time between the beginning of the symptoms and the lowering of intraocular pressure of 21.02 (±12.9) hours. In affected APAC eyes and contralateral APAC eyes, we found respectively the following means (± SD) for the parameters: 1. Spherical equivalent: +2.15 (±1.91) / +1.69 (±3.19) diopters; 2. Central corneal thickness: 530 (±49.84) / 532 (±25.87) µm; 3. Anterior chamber depth: 2.20 (±0.14) / 2.17 (±0.13) mm; 4. Axial length: 21.57 (±0.89) / 22.12 (±0.92) mm; 5. Visual field mean defect (MD): 6.52 (±6.67) / 7.45 (±8.18); 6. Corrected low variance (CLV): 18.48 (±15.48) / 24.77 (±14.96); 7. Total RNFL thickness:100.7 (±46.55) / 98.5 (±5.47) µm; 8. Superior temporal RNFL thickness: 139.83 (±57.0) / 133.2 (±21.32) µm; 9. Temporal RNFL thickness: 72.75 (±16.2) / 72.0 (±8.46) µm; 10. Inferior temporal RNFL thickness: 161.42 (±57.28) / 148.2 (±12.98) µm; 11. Superior nasal RNFL thickness:126.75 (±60.28) / 109.0 (±35.2) µm; 12. Nasal RNFL thickness: 83.42 (±25.29) / 67.3 (±8.52) µm; 13. Inferior nasal RNFL thickness:130.75 (±76.76) / 119.0 (±26.5) µm. We know that our results are limited because of the small number of cases, however our study is not finished and we intend to improve it with more patients.
In affected APAC eyes there is a slightly increase of RNFL thickness probably due to an edematous phase just after the attack, and also a slightly increase in visual field defects due to RNFL damage.
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