June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Longitudinal and Cross-Sectional Analyses of Age and Intraocular Pressure Effects on Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness
Author Affiliations & Notes
  • Xinbo Zhang
    Casey Eye Institute, Oregon Health & Science University, Portland, OR
  • Brian A Francis
    Doheny Eye Institute, Los Angeles, CA
  • Ou Tan
    Casey Eye Institute, Oregon Health & Science University, Portland, OR
  • Rohit Varma
    Ophthalmology, University of Southern California, Los Angeles, CA
  • David S Greenfield
    Bascom Palmer Eye Institute, University of Miami, Miami, FL
  • Joel S Schuman
    University of Pittsburgh, Pittsburgh, PA
  • Nils A Loewen
    University of Pittsburgh, Pittsburgh, PA
  • Mitra Sehi
    Bascom Palmer Eye Institute, University of Miami, Miami, FL
  • David Huang
    Casey Eye Institute, Oregon Health & Science University, Portland, OR
  • Footnotes
    Commercial Relationships Xinbo Zhang, None; Brian Francis, None; Ou Tan, Optovue (F), Optovue (P); Rohit Varma, None; David Greenfield, None; Joel Schuman, None; Nils Loewen, None; Mitra Sehi, None; David Huang, Optovue (F), Optovue (P), Zeiss Meditec (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4574. doi:
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      Xinbo Zhang, Brian A Francis, Ou Tan, Rohit Varma, David S Greenfield, Joel S Schuman, Nils A Loewen, Mitra Sehi, David Huang, ; Longitudinal and Cross-Sectional Analyses of Age and Intraocular Pressure Effects on Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4574.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To study the effect of age and intraocular pressure (IOP) on retinal nerve fiber layer (NFL) and ganglion cell complex (GCC) thickness in normal eyes.

Methods: We analyzed the data from subjects enrolled in the multi-center longitudinal Advanced Imaging for Glaucoma (AIG) Study (www.AIGStudy.net). The data included yearly visits from the normal subjects group in the AIGS study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of NFL and GCC three times on each visit. To adjust for the repeated measurements for the same subjects, mixed effect models were used to evaluate the longitudinal effect of age and IOP on the NFL and GCC thickness. The measurements at baseline were used to examine the cross sectional effects among individual subjects.

Results: The analysis included 192 eyes of 92 normal participants with follow-up visits between 2009 and 2013. The longitudinal analyses showed the overall GCC thickness on average decreased 0.25 μm per year (p <0.001, standard error = 0.049), while the overall NFL thickness decreased 0.21 μm per year (p<0.001, standard error = 0.04). The cross-sectional analyses showed the GCC thickness was 0.17 μm thinner for each year older (p<0.001, standard error = 0.050), while the RNFL was 0.19 μm thinner for each year older (p=0.003, standard error = 0.065). We did not find significant IOP effect on either GCC or RNFL from either longitudinal or cross-sectional analysis.

Conclusions: NFL and GCC thin with age; they do not seem to be affected by IOP. These results on normal age-related thinning of NFL and GCC can be used to establish criteria to detect abnormally rapid thinning that might indicate glaucomatous progression.

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