June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Visual outcomes of eyes with neovascular age-related macular degeneration requiring frequent ranibizumab when switched to aflibercept
Author Affiliations & Notes
  • Abdallah Ellabban
    Department of Ophthalmology, Cheltenham General Hospital, Chletenham, United Kingdom
  • Ahmed Sallam
    Department of Ophthalmology, Cheltenham General Hospital, Chletenham, United Kingdom
  • Vasileios Petousis
    Department of Ophthalmology, Cheltenham General Hospital, Chletenham, United Kingdom
  • Emily Fletcher
    Department of Ophthalmology, Cheltenham General Hospital, Chletenham, United Kingdom
  • Quresh Mohamed
    Department of Ophthalmology, Cheltenham General Hospital, Chletenham, United Kingdom
  • Robert Johnston
    Department of Ophthalmology, Cheltenham General Hospital, Chletenham, United Kingdom
  • Footnotes
    Commercial Relationships Abdallah Ellabban, None; Ahmed Sallam, None; Vasileios Petousis, None; Emily Fletcher, None; Quresh Mohamed, None; Robert Johnston, Medisoft Limited (Electronic Medical Record system) (E)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4592. doi:
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      Abdallah Ellabban, Ahmed Sallam, Vasileios Petousis, Emily Fletcher, Quresh Mohamed, Robert Johnston; Visual outcomes of eyes with neovascular age-related macular degeneration requiring frequent ranibizumab when switched to aflibercept. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4592.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the visual outcome after switching to aflibercept (2.0 mg) in eyes with neovascular age-related macular degeneration (nAMD) that were previously required frequent re-treatment with ranibizumab (0.5 mg).

Methods: A standardized dataset defined at the beginning of the anti-VEGF era was prospectively collected in real-time within an electronic medical record system (Medisoft®) in the context of paperless clinics on 181 eyes of 161 patients with nAMD that were switched to aflibercept due to persistent exudative changes. All eyes had received least 5 intravitreal injections of ranibizumab in a 6-month period after the loading phase of 3 monthly injections before switching. After switching all eyes were treated with an initial loading phase of 3 monthly aflibercept injections followed by bi-monthly injections.

Results: The mean age was 78.9 ± 7.6 years. There were 74 males and 87 females. Best correct visual acuity (BCVA) at the point of switching to aflibercept was 59.1 ± 1.2 ETDRS letters. The mean BCVA at the switching was 59.4 ± 1.1 letters. The mean change in BCVA at 3 moths after aflibercept loading phase was -1.0 ± 2.4 letters (n=53), and was 0.5 ± 4.6 letters at 6-months follow-up (n=18).

Conclusions: In a cohort of eyes requiring frequent ranibizumab to treat neovascular age-related macular degeneration switching to aflibercept did not show any visual acuity benefits.

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