June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Lens AGEs and diabetic retinopathy progression. Preliminary Results
Author Affiliations & Notes
  • Marcelo Zas
    Ophthalmology, Hosp d'Clinicas, Univ of Buenos Aires, Ciudad Autonoma, Argentina
  • Mariano Cotic
    Ophthalmology, Hosp d'Clinicas, Univ of Buenos Aires, Ciudad Autonoma, Argentina
  • Matias Iglicki
    Ophthalmology, Hosp d'Clinicas, Univ of Buenos Aires, Ciudad Autonoma, Argentina
  • Juan Pablo Francos
    Ophthalmology, Hosp d'Clinicas, Univ of Buenos Aires, Ciudad Autonoma, Argentina
  • Natalia Ximena Minguez
    Ophthalmology, Hosp d'Clinicas, Univ of Buenos Aires, Ciudad Autonoma, Argentina
  • lucas adamo
    Ophthalmology, Hosp d'Clinicas, Univ of Buenos Aires, Ciudad Autonoma, Argentina
  • juan cortalezzi
    Ophthalmology, Hosp d'Clinicas, Univ of Buenos Aires, Ciudad Autonoma, Argentina
  • Marcos Mendaro
    Ophthalmology, Hosp d'Clinicas, Univ of Buenos Aires, Ciudad Autonoma, Argentina
  • Carmen N Demetrio
    Ophthalmology, Hosp d'Clinicas, Univ of Buenos Aires, Ciudad Autonoma, Argentina
  • pablo chiaradia
    Ophthalmology, Hosp d'Clinicas, Univ of Buenos Aires, Ciudad Autonoma, Argentina
  • Footnotes
    Commercial Relationships Marcelo Zas, None; Mariano Cotic, None; Matias Iglicki, None; Juan Pablo Francos, None; Natalia Minguez, None; lucas adamo, None; juan cortalezzi, None; Marcos Mendaro, None; Carmen Demetrio, None; pablo chiaradia, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4698. doi:
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      Marcelo Zas, Mariano Cotic, Matias Iglicki, Juan Pablo Francos, Natalia Ximena Minguez, lucas adamo, juan cortalezzi, Marcos Mendaro, Carmen N Demetrio, pablo chiaradia; Lens AGEs and diabetic retinopathy progression. Preliminary Results. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4698.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To establish the relationship between the concentration of advanced glycation end products(AGEs) and the diagnosis of the diabetic retinopathy and its status.

Methods: Twenty five different patients with diabetes were evaluated at the Hospital de Clinicas which depends on the University of Buenos Aires. <br /> The diagnosis and monitoring of patients were done by means of: symptoms, fluorescence of the lens ( measure with the device CLEARPATH), best corrected visual acuity (BCVA) and, fundus examination. Lens autofluorescence is increased in patients with diabetes mellitus, but clinical application has been limited by the lack of an instrument suitable for routine clinical use .This "fluorescence deviation" showed progressively higher values for normal, prediabetes, type 2 diabetes, and type 1 diabetes and a high degree of predictability of diabetes diagnosis. A receiver operating characteristics curve was used to determine sensitivity and specificity for prediction of diabetes type 2 .

Results: Fluorescence deviation was related with Diabetic Retinopathy and its status, a sensitivity of 70 % at 99 specificity was observed detection of type 2 diabetes and its classification

Conclusions: The statistically significant difference between fluorescence deviations of normal and type 2 diabetes supports the feasibility of lens autofluorescence to screen subjects for undiagnosed type 2 diabetes. Ophthalmic practices are points of care at which there may be a public health benefit for screening patients for undiagnosed diabetes.

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