June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Feline Neovascular Vitreoretinopathy: A Histological Study of a Newly Described Cause of Feline Glaucoma
Author Affiliations & Notes
  • Richard R Dubielzig
    Pathobiol Sciences, Univ of Wisconsin-Madison, Madison, WI
  • Billie Beckwith-Cohen
    Pathobiol Sciences, Univ of Wisconsin-Madison, Madison, WI
  • Alison Hoffman
    Eye Care for Animals, Pasadina, CA
  • Footnotes
    Commercial Relationships Richard Dubielzig, None; Billie Beckwith-Cohen, None; Alison Hoffman, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4732. doi:
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      Richard R Dubielzig, Billie Beckwith-Cohen, Alison Hoffman; Feline Neovascular Vitreoretinopathy: A Histological Study of a Newly Described Cause of Feline Glaucoma. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4732.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To characterize the histopathology of twenty-one feline globes enucleated because of intractable glaucoma.

Methods: The submission forms of twenty-one feline globes diagnosed with neovascular vitreoretinopathy were examined retrospectively. Case histories and follow-up information were reviewed when available. Globes were examined grossly and histologically. Histological sections were stained with hematoxylin and eosin and selected special and immunohistochemical stains were used in individual cases.

Results: The median±SD age of cats diagnosed with feline neovascular vitreoretinopathy was 6±14 months. Eighteen cats were domestic, 2 were Persian and one was a British shorthair. All cats (21/21) had clinical or histological signs of glaucoma and buphthalmos. Intraocular pressure measurements were available for twelve cats and had a median±SD of 47±11mmHg. Histologically in 21/21 globes the peripheral retina was avascular and gliotic and there were epiretinal vascular profiles extending from the peripapillary retina into the vitreous. Other common histological abnormalities included: anterior segment dysgenesis (20/21), retinal detachment (20/21), lymphoplasmacytic anterior uveitis (18/21), preiridal fibrovascular membranes (21/21), peripheral anterior synechia (19/21), and ectropion uvea in 16/18 eyes where the pupillary margin was sampled. Keratitis was present in 14/21 globes, likely secondary to exposure. The status of the fellow eye was known in seventeen cats: the fellow eye was variably affected in ten. Physical examination results were available for thirteen cats and were otherwise unremarkable.

Conclusions: Feline neovascular vitreoretinopathy is a rare disease of kittens and young cats. Either one or both eyes may be involved and cats often present with multiple ocular abnormalities. Etiology remains unknown.

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