June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Using Multifocal Steady-State Visual Evoked Potentials for Objective Assessment of Visual Field Loss in Glaucoma
Author Affiliations & Notes
  • Yuan-Pin Lin
    Institute for Neural Computation, University of California, San Diego, La Jolla, CA
  • Yijun Wang
    Institute for Neural Computation, University of California, San Diego, La Jolla, CA
  • Tzyy-Ping Jung
    Institute for Neural Computation, University of California, San Diego, La Jolla, CA
  • Carolina Gracitelli
    Ophthalmology, University of California San Diego, La Jolla, CA
    Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
  • Ricardo Yuji Abe
    Ophthalmology, University of California San Diego, La Jolla, CA
  • Saif Baig
    Ophthalmology, University of California San Diego, La Jolla, CA
  • Felipe A Medeiros
    Ophthalmology, University of California San Diego, La Jolla, CA
  • Footnotes
    Commercial Relationships Yuan-Pin Lin, None; Yijun Wang, None; Tzyy-Ping Jung, None; Carolina Gracitelli, None; Ricardo Abe, None; Saif Baig, None; Felipe Medeiros, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 486. doi:
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      Yuan-Pin Lin, Yijun Wang, Tzyy-Ping Jung, Carolina Gracitelli, Ricardo Yuji Abe, Saif Baig, Felipe A Medeiros; Using Multifocal Steady-State Visual Evoked Potentials for Objective Assessment of Visual Field Loss in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):486.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

This study aimed to develop an electroencephalogram (EEG)-based brain sensing technique for objective assessment of visual field defects in glaucoma using multifocal steady-state visual-evoked potentials (mfSSVEPs).

 
Methods
 

This study hypothesized that while presenting multiple frequency-tagged flickering sectors (alternating black/white) in the monocular visual field, a sector(s) corresponding to a visual field deficit(s) would be less perceivable or unperceivable and thereby would lead to weaker SSVEP amplitude with stronger inter-trial variability, compared to healthy spots. To test the hypothesis, we designed a layout of visual stimuli consisting of 20 sectors in three concentric rings (subtending 6°, 15°, and 25° in the visual field) for eliciting mfSSVEPs. All sectors flickered concurrently at frequencies from 8 to 11.8 Hz with a step of 0.2 Hz. MfSSVEPs from 14 patients with asymmetric glaucomatous visual field defects on standard automated perimetry (SAP) were recorded while their monocular visual fields were exposed to the stimulation (5 seconds per trial, 100 trials per eye). We evaluated the relationship between asymmetry in visual field sensitivity (in 1/L scale) and mfSSVEP asymmetries (amplitude and inter-trial variability).

 
Results
 

SAP sensitivity asymmetry was positively correlated with mfSSVEP amplitude asymmetry (Figure A) but negatively related to the mfSSVEP variability asymmetry (Figure B). The obtained multivariable model containing mfSSVEP amplitude and inter-trial variability had an R2 of 70% for explaining SAP results (p < 0.001).

 
Conclusions
 

This study demonstrated that the mfSSVEP dynamics in terms of amplitude and inter-trial variability are capable of serving as objective biomarkers to assess visual field loss in glaucoma.  

 
Figure. Results of mfSSVEP in 14 subjects with asymmetric glaucoma. Relationships between SAP sensitivity asymmetry versus (A) mfSSVEP amplitude asymmetry and versus (B) mfSSVEP inter-trial variability asymmetry.
 
Figure. Results of mfSSVEP in 14 subjects with asymmetric glaucoma. Relationships between SAP sensitivity asymmetry versus (A) mfSSVEP amplitude asymmetry and versus (B) mfSSVEP inter-trial variability asymmetry.

 
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