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Angela Nicole Baldwin, Shane Griffin, Nicolas Sippl-Swezey, Panagiota Loumou, Jaskiran Mann, Ravi Keshavamurthy, Travis Porco, Austin Roorda, Jacque L Duncan; Cone spacing measures over 12 months in eyes with retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4926.
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To determine the inter-visit, inter-grader and inter-ocular variability of Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO)-derived cone spacing measures in eyes with retinal degenerations (RD) followed for 12 months.
Six patients with inherited RD including retinitis pigmentosa and choroideremia underwent AOSLO imaging at 3 visits (2 baseline visits separated by no more than 1 month and one visit 12 months after the first visit). Cone spacing was measured in multiple regions in each image by 2 independent graders. Variability of cone spacing measures between visits and between graders was determined. Standard macular measures, including visual acuity, foveal sensitivity, Goldmann perimetry, static perimetry in the central 20 degrees, and spectral-domain optical coherence tomography (SD-OCT)-derived outer segment length and inner/outer segment junction or Ellipsoid Zone (EZ) band width were obtained.
Overall, cone spacing was measured in 309 regions. Agreement between graders for cone spacing measures at each location and each visit was acceptable (intraclass correlation (ICC=0.75, 95% CI 0.61-0.87); mean difference between graders was 0.08 arcminutes (95% CI 0.07-0.1). Cone spacing measures were similar at the two baseline visits; median absolute difference was 0.044 arcmin (95% CI= 0.041-0.057). Cone spacing measures at 12 months compared to spacing measures at baseline increased by 0.027 arcminutes (95% CI 0.02-0.04). There were no significant changes in standard clinical measures of disease progression including visual acuity, foveal threshold, area of I4e and V4e kinetic isopters, sensitivity in the central 20 degrees, EZ band width or outer segment thickness in the central 3 degrees.
Cone spacing measures using AOSLO showed substantial inter-grader agreement. Measures were similar between baseline visits separated by less than 1 month. Cone spacing increased over 12 months in eyes with inherited RD, although standard clinical measures showed no significant change during this period. This information establishes the repeatability for current and future clinical trials involving AOSLO imaging of eyes with inherited RD.
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