June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Extrafoveal Cone Packing Density and Geometry in Retinopathy of Prematurity (ROP)
Author Affiliations & Notes
  • Ramkumar Ramamirtham
    Ophthalmology, Boston Children's Hospital, Boston, MA
  • Garima Soni
    Ophthalmology, Boston Children's Hospital, Boston, MA
    Psychology, Northeastern University, Boston, MA
  • James D Akula
    Ophthalmology, Boston Children's Hospital, Boston, MA
    Ophthalmology, Harvard Medical School, Boston, MA
  • Emily A Swanson
    Ophthalmology, Boston Children's Hospital, Boston, MA
  • Tara L Favazza
    Ophthalmology, Boston Children's Hospital, Boston, MA
  • Mircea Mujat
    PSI Corp, North Andover, MA
  • R Daniel Ferguson
    PSI Corp, North Andover, MA
  • Toco Yuen Ping Chui
    Department of Ophthalmology, New York Eye & Ear Infirmary, New York, NY
  • Anne Moskowitz
    Ophthalmology, Boston Children's Hospital, Boston, MA
    Ophthalmology, Harvard Medical School, Boston, MA
  • Anne B Fulton
    Ophthalmology, Boston Children's Hospital, Boston, MA
    Ophthalmology, Harvard Medical School, Boston, MA
  • Footnotes
    Commercial Relationships Ramkumar Ramamirtham, None; Garima Soni, None; James Akula, None; Emily Swanson, None; Tara Favazza, None; Mircea Mujat, PSI Corp (E), PSI Corp (E); R Ferguson, PSI Corp (E); Toco Chui, None; Anne Moskowitz, None; Anne Fulton, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4933. doi:
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      Ramkumar Ramamirtham, Garima Soni, James D Akula, Emily A Swanson, Tara L Favazza, Mircea Mujat, R Daniel Ferguson, Toco Yuen Ping Chui, Anne Moskowitz, Anne B Fulton; Extrafoveal Cone Packing Density and Geometry in Retinopathy of Prematurity (ROP). Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4933.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To study cone packing density and geometry using an adaptive optics scanning laser ophthalmoscope (AOSLO) in eyes with history of ROP and age matched control subjects.

Methods: Subjects with a history of severe, treated ROP (n=3, SROP), with a history of mild ROP that resolved without treatment (n=3, MROP), and term born controls (n=6, CT) were studied. The subjects were aged 15-23 (median: 19.8) years at test. Two to four confocal and offset-pinhole AOSLO videos (64 frames) subtending 1°×1° visual angle were obtained from each subject at retinal eccentricities 4.5°, 9°, 13.5° and 18° (Chui et al, Biomed Opt Exp, 2012) by directing the subjects’ gaze using a fixation target. Offline, non-rigid registration was used to obtain a final image for analysis. Cones were counted using a custom MATLAB program and cone geometry was assessed by fit of Voronoi polynomials. Cone density (cones/mm2) was estimated after correction of the image magnification based on axial lengths (ROP = 22.5 ± 1.11 mm vs. CT = 23.6 ± 1.10 mm). Effects of group and eccentricity were detected by repeated-measures ANOVA.

Results: Cone density decreased with increasing retinal eccentricity (4.5° to 13.5°) in all groups. Cone density was markedly lower in SROP than in CT and MROP eyes (p<0.01); however, image quality was also lower in SROP subjects. The Voronoi polygons were significantly more irregular in SROP than in MROP and CT eyes (p< 0.05).

Conclusions: SROP (but not MROP) subjects displayed reduced number and organization of cone photoreceptors. This may indicate loss of cone photoreceptors, consistent with recognized visual deficits in SROP subjects. Alternatively, low cone counts maybe due to the relatively poor quality of images obtained from SROP eyes.

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