June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Correlation of Optical Biometry, Gonioscopy and Scheimpflug Imaging with Spectral Domain OCT Angle metrics
Author Affiliations & Notes
  • Anna Dastiridou
    Doheny Eye Institute, Los Angeles, CA
  • Ken Marion
    Doheny Eye Institute, Los Angeles, CA
  • Ramya Swamy
    Doheny Eye Centers, Los Angeles, CA
  • Alex Huang
    Doheny Eye Institute, Los Angeles, CA
    Doheny Eye Centers, Los Angeles, CA
  • Srinivas R Sadda
    Doheny Eye Institute, Los Angeles, CA
    Doheny Eye Centers, Los Angeles, CA
  • Brian Francis
    Doheny Eye Institute, Los Angeles, CA
    Doheny Eye Centers, Los Angeles, CA
  • Vikas Chopra
    Doheny Eye Institute, Los Angeles, CA
    Doheny Eye Centers, Los Angeles, CA
  • Footnotes
    Commercial Relationships Anna Dastiridou, None; Ken Marion, None; Ramya Swamy, None; Alex Huang, None; Srinivas Sadda, Carl Zeiss Meditec (C), Carl Zeiss Meditec (F), Carl Zeiss Meditec (R); Brian Francis, None; Vikas Chopra, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4991. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Anna Dastiridou, Ken Marion, Ramya Swamy, Alex Huang, Srinivas R Sadda, Brian Francis, Vikas Chopra; Correlation of Optical Biometry, Gonioscopy and Scheimpflug Imaging with Spectral Domain OCT Angle metrics. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):4991.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To compare angle metrics with spectral domain OCT in phakic and pseudophakic eyes and to investigate their relation with gonioscopy, biometry and Scheimpflug imaging.

Methods: Phakic and pseudophakic patients from the Glaucoma and Comprehensive clinics of the Doheny Eye Centers were prospectively enrolled. Patients with previous surgical procedures, other than uneventful phacoemulsification, were excluded.<br /> All participants underwent gonioscopy by a glaucoma expert. Optical biometry and Scheimpflug imaging were performed to measure axial length, anterior chamber depth (ACD) and anterior chamber angle (ACA). Spectral domain OCT images of the inferior angle were acquired and Schwalbe’s line angle opening distance (SL-AOD) and SL trabecular iris space area (SL-TISA) were measured with ImageJ.

Results: The pseudophakic group (68 eyes) had significantly larger ACD (p<0.001), larger ACA (p<0.001), and greater gonioscopic grades (p<0.001) compared with the phakic group (67 eyes), despite the absence of a difference in axial length between the groups (p=0.154).<br /> SL-AOD was 533±310μm in the phakic and 744±227 in the pseudophakic group (p<0.001). Likewise, SL-TISA was larger in the pseudophakic compared to the phakic group (0.268±0.934 versus 0.195±0.126 mm2, p<0.001). There was a moderate positive correlation between SL-AOD/SL-TISA and axial length (r=0.313/0.322), ACD (r=0.459/0.379), gonioscopic grade (r=0.555/0.520) and ACA (r=0.625/0.587) (all p<0.001). In multiple regression analysis, ACA was the most significant parameter that could predict SL-AOD in the model (R2=0.452), while adding ACD and gonioscopy grade in a stepwise approach, increased the model fit to an R2 of 0.625 (all p<0.001).

Conclusions: Angle metrics are larger in pseudophakic eyes compared to phakic eyes, as measured by spectral domain OCT. Biometry, gonioscopy and Scheimpflug imaging can provide measurements that partially explain the variability in SL-based metrics with OCT.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×