June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Efficacy of the EX-PRESS glaucoma drainage device in the treatment of glaucoma
Author Affiliations & Notes
  • Michael Holmboe
    Ophthalmology, University of Colorado Denver, Centennial, CO
    Rocky Vista University College of Osteopathic Medicine, Parker, CO
  • Malik Y Kahook
    Ophthalmology, University of Colorado Denver, Centennial, CO
  • Robert Shields
    Ophthalmology, University of Colorado Denver, Centennial, CO
  • Leonard Seibold
    Ophthalmology, University of Colorado Denver, Centennial, CO
  • Footnotes
    Commercial Relationships Michael Holmboe, None; Malik Kahook, None; Robert Shields, None; Leonard Seibold, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5016. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Michael Holmboe, Malik Y Kahook, Robert Shields, Leonard Seibold; Efficacy of the EX-PRESS glaucoma drainage device in the treatment of glaucoma. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5016.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To study the two-year outcomes of the EX-PRESS glaucoma drainage device in glaucoma patients and identify risk factors for failure.

Methods: Retrospective review of consecutive eyes that underwent implantation of an EX-PRESS glaucoma drainage device under a scleral flap between 2009 and 2013. All procedures were performed by a single surgeon using a standard technique with a limbal-based conjunctival flap and intraoperative mitomycin C application. Complete success was defined as an intraocular pressure (IOP) ≥5 and ≤21 mmHg without the use of glaucoma medication. Qualified success was defined by the same IOP range with or without concomitant glaucoma medication. Failure was defined as IOP <5 or >21 mmHg, loss of light perception vision, or reoperation for glaucoma. Diabetes, ethnicity, number of preoperative medications, and previous eye surgeries were examined as risk factors for failure.

Results: A total of 118 glaucomatous eyes from 98 patients were analyzed. Mean follow-up period was 359.8 ± 316.3 days. Mean IOP was reduced from 22.1 mmHg preoperatively to 14.3 and 14.5 mmHg at 1 and 2 years of follow-up, respectively. Mean medication use dropped from 2.4 preoperatively to 1.0 at 2 years postoperatively. Complete success rates were 80% at 6 months, 68% at 1 year, and 42% at 2 years of follow up. Qualified success rates were 82%, 72%, and 69% at the same time intervals respectively. Cox proportional hazard ratios failed to show a significant predictor of success (Diabetes 1.64, caucasian 0.78, number of preoperative medications 1.3, prior surgery 1.1; p>0.05 for all).

Conclusions: Implantation of the EX-PRESS glaucoma drainage device is an effective surgical method for reducing intraocular pressure in uncontrolled glaucoma.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×