June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Multifunctional OCT imaging of macular degeneration for vasculature, RPE and choroid investigation
Author Affiliations & Notes
  • Young-Joo Hong
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Masahiro Miura
    Ibaraki Medical Center, Department of Ophthalmology, Tokyo Medical University, Ami, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Shuichi Makita
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Deepa Kasaragod
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Satoshi Sugiyama
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    New Development, Tomey Corporation, Nagoya, Japan
  • Yoshiaki Yasuno
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Footnotes
    Commercial Relationships Young-Joo Hong, TOMEY CORPORATION (F), TOPCON CORPORATION (F); Masahiro Miura, Norvatis (R); Shuichi Makita, TOMEY CORPORATION (F), TOMEY CORPORATION (P), TOPCON CORPORATION (F); Deepa Kasaragod, TOMEY CORPORATION (F), TOPCON CORPORATION (F); Satoshi Sugiyama, TOMEY CORPORATION (E); Yoshiaki Yasuno, TOMEY CORPORATION (F), TOMEY CORPORATION (P), TOPCON CORPORATION (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5131. doi:
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      Young-Joo Hong, Masahiro Miura, Shuichi Makita, Deepa Kasaragod, Satoshi Sugiyama, Yoshiaki Yasuno; Multifunctional OCT imaging of macular degeneration for vasculature, RPE and choroid investigation. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5131.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

In order to investigate eyes of age-related macular degeneration (AMD) comprehensively, 1-μm Jones-matrix multifunctional optical coherence tomography (JM-OCT) imaging was performed. This study aims at evaluating clinical utility of JM-OCT imaging, based on a descriptive case series of AMD.

 
Methods
 

Eight eyes of 4 AMD cases, including 4 end stage AMD, 1 early stage AMD, 1 drusen, and 2 drusenoid pigment epithelial detachment were imaged with JM-OCT.6 mm × 6 mm areas around the diseased region were scanned with 512 × 1024 A-lines in 6.6 seconds. Intensity OCT, complex decorrelation OCT, birefringence tomography, and degree-of-polarization-uniformity (DOPU) tomography were calculated from a single scan and each tomography represents the structure, vasculature, sub-resolution microstructural property of the tissue, and melanin pigmentation. DOPU and complex decorrelation signals were combined to provide comprehensive angiography.

 
Results
 

Anormality of retinal pigment epithelium (RPE) was imaged with high DOPU (less pigment) in 4 of 4 end stage AMD cases, and it was corresponding to the hypo-fluorescence of short-wavelength autofluorescence (SW-AF) image. In another 4 eyes, SW-AF did not show hypo-fluorescence and their RPE showed low DOPU (pigmented). High birefringence band structure was observed in sclera with less pigment (high DOPU signal) in 3 eyes of end stage AMD.<br /> Figure 1 shows a representative case of AMD. High contrast choroidal vasculature and hypo-fluorescence were observed in the abnormal RPE region from near infrared (NIR) AF (a) and SW-AF (b) images, respectively. And the en face projection (c) of complex decorrelation (g) showed similar appearance with NIR-AF, in addition DOPU B-scan (h) showed depth resolved melanin pigment distribution (arrowheads indicate abnormal RPE). In this region, intensity OCT B-scan (d) showed higher penetration into sclera. Birefringence B-scan (f) showed layered structure in the sclera (dashed circle) as high birefringence at anterior sclera (green) and low birefringence (blue) at posterior. The sclera was appeared with high DOPU (less pigment). DOPU encoded complex decorrelation angiography (d) showed distinguished choroidal vasculature at the region of abnormal RPE and less pigmented choroid.

 
Conclusions
 

The multifunctional imaging with JM-OCT gives comprehensive information about the vasculature, RPE, and choroid with depth resolved imaging.  

 
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