June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Factors influencing choroidal thickness measurements using swept-source optical coherence tomography
Author Affiliations & Notes
  • Albert Caramoy
    Department of Ophthalmology, University of Cologne, Cologne, Germany
  • Bernd Kirchhof
    Department of Ophthalmology, University of Cologne, Cologne, Germany
  • Claus Cursiefen
    Department of Ophthalmology, University of Cologne, Cologne, Germany
  • Ludwig M Heindl
    Department of Ophthalmology, University of Cologne, Cologne, Germany
  • Footnotes
    Commercial Relationships Albert Caramoy, None; Bernd Kirchhof, None; Claus Cursiefen, None; Ludwig Heindl, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5289. doi:
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      Albert Caramoy, Bernd Kirchhof, Claus Cursiefen, Ludwig M Heindl; Factors influencing choroidal thickness measurements using swept-source optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5289.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To study the variability of choroidal thickness in subjects without macular pathology and its influencing factors using swept-source optical coherence tomography.<br />

Methods: In 123 volunteers without macular pathology swept-source optical coherence tomography was performed (DRI OCT-1, TopCon Corporation, Japan). The Early Treatment Diabetic Retinopathy Study (ETDRS) grid was centered manually at the fovea. The following retinal layers were delineated automatically: RETINA=total retinal thickness from internal limiting membrane to Bruch’s membrane, CSI=choroid sclera interface. The retinal layers were analyzed using multiple regressions with respect to gender, age, axial length and day time.

Results: Mean age was 33.40 ± 16.36 years. Forty five men and 78 women were analyzed. Mean RETINA was 285.85 ± 14.53 µm and 287.18 ± 12.93 µm for the right and left eye respectively. Mean CSI was 273.94 ± 77.77 and 271.19 ± 78.85 µm for the right and left eye respectively. The assumptions of linearity, independence of errors, homoscedasticity, unusual points and normality of residuals were met. The RETINA correlated significantly for gender, age and axial length (all p values < 0.05), however no significant correlation was found with regard to day time (p=0.579). CSI correlated also significantly for gender, age and axial length (all p values < 0.05), but not significantly for day time (p=0.249). Among these values CSI was only moderately negatively correlated with axial length (r= -0.44, p<0.001).<br />

Conclusions: Swept-source optical coherence tomography and the use of 1,050 nm wavelength allow rapid measurements of the choroid. Total retinal thickness and choroid sclera interface were influenced by gender, age and axial length. No correlation with regard to day time was found.

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