June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Retinal pigment epithelial atrophy in treated and fellow eye of patients receiving anti-vascular endothelial growth factor for neovascular age-related macular degeneration. A three years follow-up study
Author Affiliations & Notes
  • Giulia Delledonne
    Sacco Hospital Eye Clinic, Department of Biomedical and Clinical Sciences, Milano, Italy
  • Roberta Secondi
    Sacco Hospital Eye Clinic, Department of Biomedical and Clinical Sciences, Milano, Italy
  • Ermengarda Marziani
    Sacco Hospital Eye Clinic, Department of Biomedical and Clinical Sciences, Milano, Italy
  • Alessandra Acquistapace
    Sacco Hospital Eye Clinic, Department of Biomedical and Clinical Sciences, Milano, Italy
  • Alba Xhepa
    Sacco Hospital Eye Clinic, Department of Biomedical and Clinical Sciences, Milano, Italy
  • Mario V Cigada
    University of Milan, Ophthalmology, Milano, Italy
  • Sara Bochicchio
    Sacco Hospital Eye Clinic, Department of Biomedical and Clinical Sciences, Milano, Italy
  • Giovanni Staurenghi
    Sacco Hospital Eye Clinic, Department of Biomedical and Clinical Sciences, Milano, Italy
  • Footnotes
    Commercial Relationships Giulia Delledonne, None; Roberta Secondi, None; Ermengarda Marziani, None; Alessandra Acquistapace, None; Alba Xhepa, None; Mario Cigada, None; Sara Bochicchio, None; Giovanni Staurenghi, Alcon Laboratories, Inc (C), Allergan, Inc (C), Bayer (C), Boehringer (C), Genentech (C), GlaxoSmithKline (C), Heidelberg Engineering (C), Novartis Pharmaceuticals Corporation (C), Novartis Pharmaceuticals Corporation (S), Ocular Instruments, Inc. (P), Optos, Inc. (C), Optovue (S), Roche (C), Zeiss (C), Zeiss (S)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5354. doi:
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      Giulia Delledonne, Roberta Secondi, Ermengarda Marziani, Alessandra Acquistapace, Alba Xhepa, Mario V Cigada, Sara Bochicchio, Giovanni Staurenghi; Retinal pigment epithelial atrophy in treated and fellow eye of patients receiving anti-vascular endothelial growth factor for neovascular age-related macular degeneration. A three years follow-up study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5354.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the occurrance of retinal pigment epithelial (RPE) atrophy in patients with treatment-naive choroidal neovascularization (CNV) in age-related macular degeneration undergoing anti-vascular endothelial growth factor therapy (anti-VEGF) comparing treated and fellow eye.

Methods: 56 patients with naïve CNV (occult-type 1, classic-type 2 and RAP-type 3) receiving anti-VEGF therapy were retrospectively evaluated for a 3-years period. Areas of RPE atrophy were identified by different readers using infrared reflectance, fundus autofluorescence (wavelength 488 nm) imaging and spectral domain optical coherence tomography. Measures of atrophy was performed by a semiautomated software (Region Finder, Heidelberg Engineering, Heidelberg, Germany). Atrophy was measured in treated and fellow, unaffected eye.

Results: Of 56 patients (112 eyes), 40 were treated with anti-VEGF for unilateral CNV (group 1) and 16 for bilateral CNV (group 2). Precisely 72 of 112 eyes received anti-VEGF treatment.<br /> Within the group 1, atrophy occurred: in the treated eye in 11 patients (27,5%), in the fellow eye in 5 patients (12,5%), in both eyes in 4 patients (10%). No atrophy was developed in 20 (50%).<br /> Within the group 2, atrophy occurred in 9 patients (56%) meanwhile no atrophy was developed in 7 (44%). Considering the total number of anti-VEGF injected eyes, 36% developed atrophy and 64% did not.

Conclusions: The study showed no considerable differences between anti-VEGF treated and unaffected fellow eyes in the growth of RPE atrophy.

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