June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
The long-term changes in axial length and refraction and the characteristics of Fourier domain-OCT in children with syndrome of myelinated retinal nerve fibers, axial myopia and amblyopia
Author Affiliations & Notes
  • Yang Shen
    Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
  • Ling Sun
    Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
  • Peijun Yao
    Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
  • Jooyeon Son
    Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
  • Mi Tian
    Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
  • Xingtao Zhou
    Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
  • Footnotes
    Commercial Relationships Yang Shen, None; Ling Sun, None; Peijun Yao, None; Jooyeon Son, None; Mi Tian, None; Xingtao Zhou, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 540. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Yang Shen, Ling Sun, Peijun Yao, Jooyeon Son, Mi Tian, Xingtao Zhou; The long-term changes in axial length and refraction and the characteristics of Fourier domain-OCT in children with syndrome of myelinated retinal nerve fibers, axial myopia and amblyopia. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):540.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

To investigate the long-term changes in axial length and refraction and the characteristics of Fourier domain-optical coherence tomography in children with syndrome of myelinated retinal nerve fibers (MRFN), axial myopia and amblyopia.

 
Methods
 

Ten children (4.40±2.22 years, 4 boys and 6 girls) with the syndrome of MRNF, axial myopia and amblyopia were recruited in this prospective self-controlled study. Each eye underwent routine ophthalmic examinations, including axial length (AL), cycloplegic refraction, best-corrected distance visual acuity (BDVA), simultaneous perception, cover test, corneal curvature, anterior segment and fundus examinations. Spectacles or rigid gas permeable contact lenses (RGP) were used for refractive correction. Part-time occlusion therapy (6-8 hours per day) was employed for amblyopia. Lesion areas and macular thicknesses were examined only on the final visit. Statistical analysis was performed using SPSS 19 software. Cut-off P values were 0.05.

 
Results
 

The follow-up periods ranged from 1.17 to 9.75 years (mean 4.00±2.40 years). No one dropped out. Two affected eyes had a final BDVA of 20/25; four had 20/60 or better; eight were better than 20/200 and one was worse than 20/200. Nine fellow eyes were 20/25 or better. Six children had normal simultaneous perception. AL and spherical equivalent were both significantly different over time and between groups (P<0.0001), but no time*group interaction effect (P>0.05) was observed. The differences in the corneal curvature, annual mean rate of axial elongation (AMR-AE), annual mean rate of refractive growth (AMR-RG), foveal thickness and parafoveal thickness between the two groups were not significant (P>0.05). The mean perifoveal thickness in the affected eyes was significantly higher than that of the control eyes (P=0.047). In the treatment group, the occlusion dose correlated positively with final BDVA (R=0.764, P=0.016) but did not correlate with the AMR-AE, or AMR-RG (P>0.05).

 
Conclusions
 

The affected eyes and the fellow eyes show similar developmental processes in AL and refraction. Part-time occlusion therapy may have no effect on axial elongation or refractive growth but may have positive effect on visual improvement.  

 
The color fundus photographs on the last visit
 
The color fundus photographs on the last visit
 
 
The affected area revealed by the FD-OCT and the Fundus camera
 
The affected area revealed by the FD-OCT and the Fundus camera

 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×