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Tingjun Chen, ; Changes of CXCL12, CXCL14 and PDGF levels in the brain of patients with idiopathic demyelinating optic neuritis and neuromyelitis optica. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5532.
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The CXC chemokines (CXC-motif ligand 12 and CXC-motif ligand 14) and platelet-derived growth factor are suggested to modulate remyelination in the course of many demyelinating diseases. The present study compared the difference in the brain levels of these chemokines between patients with idiopathic demyelinating optic neuritis (IDON) and neuromyelitis optica (NMO) by measuring concentrations of these chemokines in the cerebrospinal fluid using an enzyme linked immunosorbent assay.
<br /> In this study, PDGF, CXCL12 and CXCL14 levels in the CSF of IDON and NMO patients were measured by ELISA and compared , and non-inflammatory neural disease (NIND) patients were used as negative control as reported by others .
<br /> Our data indicate that the prognosis of neuritis depends on the remyelinating process that is impaired due to decreased chemokines. The much lower levels of chemokines would specifically indicate the severe neuritis, such as NMO.
<br /> In conclusion, the present study strongly suggests that chemokines, PDGF, CXCL12 and CXCL14, may alone and/or together associate with these two types of ON. The former two would serve to stimulate the maturation of OPCs, and the last one is a possible OPC maturation inhibitor.
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