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Annalisa Costa, Christian Cordano, Antonella Panizzi, Laura Landi, Federico Bisio, Alessandro Bagnis, Carlo Enrico Traverso, antonio uccelli, Antonio Ferreras, Michele M Iester; Evaluation of ganglion cell complex after optic neuritis by OCT. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5536.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the macular assessment and RNFL thickness by using two different OCTs: a time domain (TD) and a spectral domain (SD) OCT, in patients with unilateral optic neuritis.
This is a retrospective study. 34 multiple sclerosis (MS) subjects with a single unilateral optic neuritis (ON) were included in the study. An ophthalmological examination, TD OCT and SD OCT were performed. The following parameters were selected: Superior max, Inferior max, Inferior average thickness, Superior average thickness, Average thickness and Foveal thickness from TD OCT and Average ganglion cell complex, superior ganglion cell complex, inferior ganglion cell complex, focal loss ganglion cell complex, global loss ganglion cell complex, average full retina, superior full retina, inferior full retina, focal loss full retina, global loss full retina, average outer retina, superior outer retina, inferior outer retina,focal loss outer retina, global loss outer retina from SD OCT. Student’s t-test was used to compare the two sets of data when the distribution of the data was normal. Mann-Whitney test coefficient was utilized to compare the two sets of data when they did not follow a normal distribution. The statistical power of the study ranged between 76.2 and 94.2% with an alpha of 0.05 and a beta of 0.5. Bonferroni correction was applied to Student’s t-test because otherwise we would have a significant chance of 40.1% of our finding.
In the affected eye group a reduction of the average thickness of retinal nerve fibre layer (RNFL) was found using TD OCT and the reduction was of 22.78% and the difference was statistically significant (P<0.001) between the two groups in almost all the investigated retina areas. Similar results were found when eyes were analysed with SD OCT, also when the ganglion cell layer (GCC) was considered: a reduction of 18.08% of GCC average thickness was found. No significant difference was found when the outer retina was considered.
In MS patients both OCT systems were able to detect difference between eyes with an outcome of optic neuritis and those without optic neuritis.
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