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Ari Kamei, Eiichiro Nagasaka; Multifocal Photopic Negative Response (mfPhNR) and Central Lineal Visual sensitivity in Patients with Optic Nerve Lesions. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5552.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the interrelation of mfPhNR and Central Lineal Visual Sensitivity in superior and inferior in patients with optic nerve lesions.
Thirteen eyes of thirteen volunteers with normal vision and eighteen eyes of nine patients with optic nerve lesions including normal tension glaucoma (NTG) were tested.<br /> The mfPhNR was recorded with the VERIS Science System 5.0.4. The visual stimulus was made up of 37 hexagons in an approximately 40-degree visual field, Pseudo-randomly alternating between black (5cd/m2) and white (200cd/m2) on the CRT monitor. Burian-Allen ERG Electrodes, Adult-bipolar or Pediatric-bipolar, were used for this testing. The recording time was approximately 8 min. with dilated pupils having the best-corrected visual acuity. The band pass filter of the amplifier was set from 1 to 100 Hz. The amplification and stimulus frequency were set to 10000 and 9.41 Hz (8 frames) respectively.<br /> Each trace of the mfPhNR found in superior and inferior regions was analyzed in about 10 degrees.<br /> The static visual field was examined with a central 30-2 SITA Standard program using a Humphrey Field Analyzer. The mean deviation (dB) in 10 degrees was converted to lineal visual sensitivity (1/Lambert) to apply for the analysis.<br />
There was a correlation between the amplitude of the mfPhNR and Central Lineal Visual Sensitivity in the inferior (R=0.456, P=0.012). On the other hand, there was no correlation between the amplitude of the mfPhNR and Central Lineal Visual Sensitivity in the superior (R= 0.332, P= 0.068).
We presented previously that there was a strong correlation between the amplitude of mfPhNR and Lineal Visual Sensitivity in about 20 degrees. There was less correlation between the amplitude of mfPhNR and Lineal Visual Sensitivity in about 10 degrees.
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