June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Trans-epithelial cross-linking for treatment of progressive keratoconus in eyes with thin cornea
Author Affiliations & Notes
  • Antonio Longo
    Eye Clinic, University of Catania, Catania, Italy
  • Michele Reibaldi
    Eye Clinic, University of Catania, Catania, Italy
  • Maurizio G Uva
    Eye Clinic, University of Catania, Catania, Italy
  • Caterina Gagliano
    Eye Clinic, University of Catania, Catania, Italy
  • Francesco Occhipinti
    Eye Clinic, University of Catania, Catania, Italy
  • Michele Bellino
    Eye Clinic, University of Catania, Catania, Italy
  • Vincenza Bonfiglio
    Eye Clinic, University of Catania, Catania, Italy
  • Mario Damiano Toro
    Eye Clinic, University of Catania, Catania, Italy
  • Matteo Fallico
    Eye Clinic, University of Catania, Catania, Italy
  • Teresio Avitabile
    Eye Clinic, University of Catania, Catania, Italy
  • Footnotes
    Commercial Relationships Antonio Longo, None; Michele Reibaldi, None; Maurizio Uva, None; Caterina Gagliano, None; Francesco Occhipinti, None; Michele Bellino, None; Vincenza Bonfiglio, None; Mario Toro, None; Matteo Fallico, None; Teresio Avitabile, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5822. doi:
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    • Get Citation

      Antonio Longo, Michele Reibaldi, Maurizio G Uva, Caterina Gagliano, Francesco Occhipinti, Michele Bellino, Vincenza Bonfiglio, Mario Damiano Toro, Matteo Fallico, Teresio Avitabile; Trans-epithelial cross-linking for treatment of progressive keratoconus in eyes with thin cornea. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5822.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the visual, refractive and corneal tomographic effects of trans-epithelial cross-linking (TE-CXL) in patients with progressive keratoconus (KC) and thin cornea.

 
Methods
 

Were included in this study all consecutive patients affected with progressive KC and thin cornea (thinnest < 400 microns) that have been treated with TE-CXL. Visual acuity, refraction, corneal tomographic parameters as assessed by Orbscan II, and endothelial cells density (ECD), at baseline and at last visit (minimum follow up: 2 years) were compared. KC progression was considered an increase in mean K of at least 1.5 D

 
Results
 

Were treated with TE-CXL 33 eyes of 33 patients (age 22-31 years). At baseline mean corrected distance visual acuity (CDVA) was 0.22±0.11 logMAR; SimK max was 53.3±3.7 D, and SimK min was 48.2±2.2 D. Eight eyes had stage I KC, 15 a stage II KC, 10 a stage III KC. Mean corneal thickness at thinnest point was 380±20 microns. After a mean follow-up of 31±4 months (range 25-38), a KC stabilization (with CDVA increase) was detected in 28 eyes, while a KC progression (with unchanged CVDA) was seen in 5 eyes, that were retreated. Eyes with KC progression had a greater baseline SimK’ Astigmatism (7.2±1.9 D vs 4.8±2.5 D, p=0.046) than eyes without KC progression. A 4.1% reduction in mean ECD was detected (from 2946±239 cells/mm2 to 2829±292 cells/mm2).

 
Conclusions
 

TE-CXL stabilizes keratoconus in most of eyes with thin cornea (thinnest <400 microns), for which standard CXL is contraindicated, with a limited corneal endothelium damage.

 
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