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Sawsan R Nowilaty, Amani S AlBakri, Ahmed Mousa, Nicola G Ghazi; The Choroid and Posterior Neural Retina in Posterior Microphthalmos: A Biometric and Optical Coherence Tomographic Analysis. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5903.
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© ARVO (1962-2015); The Authors (2016-present)
To expand the phenotypic characterization of posterior microphthalmos (PM) by analyzing, using standard and enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT), the retinal and choroidal thickness (RT, CT) and retinal and choroidal volume (RV, CV) as well as their spatial distribution across the macula in PM eyes, and how they correlate with biometric parameters of the globe.
Prospective comparative study of 15 PM eyes (8 patients) and 30 eyes of 15 age-matched controls. All eyes underwent refraction, axial length (AL) measurement, keratometry and macular SD-OCT in standard and EDI modes (radial and 19 horizontal raster scans). The 19 lines were manually segmented to measure the RT, CT, RV and CV in the 9 macular subfields of the ETDRS grid. The posterior pole curvature index (PPCI) was determined using the horizontal and vertical OCT scans. The RT, CT, RV and CV in PM eyes were compared to those of controls, the RT and CT distribution across the macula was evaluated in PM and controls, and the thickness and volume parameters were correlated with the refractive error, AL, keratometry and PPCI.
The retina across the entire macula was significantly thicker in PM than in normal eyes (p < 0.0001). The mean RT in the central subfield was 429μm in PM eyes compared to 262μm in controls, and 350μm in the temporal outer field in PM eyes compared to 284μm in controls (p <0.0001). The choroid throughout the macula was also substantially thicker in PM (p < 0.0001). The mean CT at the central subfield in PM was 481μm compared to 363μm in controls, and 504μm in the nasal inner subfield in PM compared to 343μm in controls (p<0.0001 for both). PM eyes had an abnormal distribution of the RT and CT across the macula with a characteristic shift of the maximum thickness of both layers to the nasal and inferior paracentral areas. Strong correlations exist between the central RV in PM and the AL, PMF height and corneal power (r =0.71; p=0.003).
PM eyes have a significantly thicker retina and choroid throughout the macula, independent of the contribution of the PMF with a characteristic shift of the maximum thickness of these tissues to the nasal and inferior paracentral areas of the macula. In PM eyes, the retinal volume at the center of the macula correlates strongly with each of the inverse AL, PMF height and corneal curvature.
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