June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
The Choroid and Posterior Neural Retina in Posterior Microphthalmos: A Biometric and Optical Coherence Tomographic Analysis
Author Affiliations & Notes
  • Sawsan R Nowilaty
    Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
  • Amani S AlBakri
    Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
  • Ahmed Mousa
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411,, Saudi Arabia
  • Nicola G Ghazi
    Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
  • Footnotes
    Commercial Relationships Sawsan Nowilaty, None; Amani AlBakri, None; Ahmed Mousa, None; Nicola Ghazi, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5903. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Sawsan R Nowilaty, Amani S AlBakri, Ahmed Mousa, Nicola G Ghazi; The Choroid and Posterior Neural Retina in Posterior Microphthalmos: A Biometric and Optical Coherence Tomographic Analysis. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5903.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To expand the phenotypic characterization of posterior microphthalmos (PM) by analyzing, using standard and enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT), the retinal and choroidal thickness (RT, CT) and retinal and choroidal volume (RV, CV) as well as their spatial distribution across the macula in PM eyes, and how they correlate with biometric parameters of the globe.

Methods: Prospective comparative study of 15 PM eyes (8 patients) and 30 eyes of 15 age-matched controls. All eyes underwent refraction, axial length (AL) measurement, keratometry and macular SD-OCT in standard and EDI modes (radial and 19 horizontal raster scans). The 19 lines were manually segmented to measure the RT, CT, RV and CV in the 9 macular subfields of the ETDRS grid. The posterior pole curvature index (PPCI) was determined using the horizontal and vertical OCT scans. The RT, CT, RV and CV in PM eyes were compared to those of controls, the RT and CT distribution across the macula was evaluated in PM and controls, and the thickness and volume parameters were correlated with the refractive error, AL, keratometry and PPCI.

Results: The retina across the entire macula was significantly thicker in PM than in normal eyes (p < 0.0001). The mean RT in the central subfield was 429μm in PM eyes compared to 262μm in controls, and 350μm in the temporal outer field in PM eyes compared to 284μm in controls (p <0.0001). The choroid throughout the macula was also substantially thicker in PM (p < 0.0001). The mean CT at the central subfield in PM was 481μm compared to 363μm in controls, and 504μm in the nasal inner subfield in PM compared to 343μm in controls (p<0.0001 for both). PM eyes had an abnormal distribution of the RT and CT across the macula with a characteristic shift of the maximum thickness of both layers to the nasal and inferior paracentral areas. Strong correlations exist between the central RV in PM and the AL, PMF height and corneal power (r =0.71; p=0.003).

Conclusions: PM eyes have a significantly thicker retina and choroid throughout the macula, independent of the contribution of the PMF with a characteristic shift of the maximum thickness of these tissues to the nasal and inferior paracentral areas of the macula. In PM eyes, the retinal volume at the center of the macula correlates strongly with each of the inverse AL, PMF height and corneal curvature.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×