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Bruno Lumbroso, Cristina Maria Savastano, Marco Rispoli, ; Characterization of Retinal Vascularization Morphology Using Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5955.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate retinal vessel morphology using Split-spectrum Amplitude-Decorrelation Angiography with Optical Coherence Tomography (SSADA-OCT) in healthy eyes.
Fifty-two eyes of 26 healthy volunteers (age range from 35 to 48 years old; mean age 41.94 years; SD: ± 4.13) were evaluated by OCT-angiography in the macular region. The protocol acquisition consisted of a 216 x 216 A-scan that was repeated five times in the same position, in 3x3 mm centered into the fovea.
All 52 eyes showed two separate vascular networks in the inner retina: the superficial network, located in the nerve fiber layer and in the ganglion cell layer, and the deep network, detected in the outer plexiform layer. The superficial and deep networks showed interconnections of vertical vessels. The reference planes to observe the two networks were defined, respectively, at 60 µm, with an inner limiting membrane reference (6 µm offset) and 30 µm with an inner plexiform layer reference (60 µm offset).
OCT-Angiography can separately detect the superficial vascular and the deep vascular networks. These networks are overlaid and seem to be fused when seen with standard angiographies. Furthermore, OCT-Angiography technology allows for the visualization of abnormal blood column and vessel wall details.
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