June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Evaluation of Neovascularization Elsewhere using Optical Coherence Tomography based Microangiography
Author Affiliations & Notes
  • Mary K Durbin
    R & D, Carl Zeiss Meditec, Inc, Dublin, CA
  • Scott Lee
    East Bay Retina Consultants, Inc., Oakland, CA
  • Cecilia Lee
    Department of Ophthalmology, University of Washington, Seattle, WA
  • Qinqin Zhang
    Department of Bioengineering, University of Washington, Seattle, WA
  • Patty Chung
    East Bay Retina Consultants, Inc., Oakland, CA
  • Kasra Attaran Rezaei
    Department of Ophthalmology, University of Washington, Seattle, WA
  • Michal Laron
    R & D, Carl Zeiss Meditec, Inc, Dublin, CA
  • Lin An
    R & D, Carl Zeiss Meditec, Inc, Dublin, CA
  • Ruikang K Wang
    Department of Ophthalmology, University of Washington, Seattle, WA
    Department of Bioengineering, University of Washington, Seattle, WA
  • Footnotes
    Commercial Relationships Mary Durbin, Carl Zeiss Meditec, Inc. (E); Scott Lee, Carl Zeiss Meditec, Inc. (C); Cecilia Lee, None; Qinqin Zhang, Carl Zeiss Meditec, Inc. (R); Patty Chung, None; Kasra Attaran Rezaei, None; Michal Laron, Carl Zeiss Meditec, Inc. (E); Lin An, Carl Zeiss Meditec, Inc. (E); Ruikang Wang, Carl Zeiss Meditec, Inc. (R)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5963. doi:
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      Mary K Durbin, Scott Lee, Cecilia Lee, Qinqin Zhang, Patty Chung, Kasra Attaran Rezaei, Michal Laron, Lin An, Ruikang K Wang; Evaluation of Neovascularization Elsewhere using Optical Coherence Tomography based Microangiography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5963.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

OCT based microangiography (OMAG) is a non-invasive imaging technique that allows 3D images of dynamic blood perfusion within the retina. This study describes the OMAG imaging characteristics of neovascularization elsewhere (NVE) in cases of proliferative diabetic retinopathy (PDR).

 
Methods
 

Three patients with PDR, diagnosed by fundus examination and fluorescein angiography (FA), were imaged with OMAG, and depth encoded en face images were generated, including an en face image located just internal to the internal limiting membrane (ILM). Clinical characteristics and funduscopic findings of NVE were correlated to OMAG images.

 
Results
 

Three cases were imaged, two with type 1 and one with type 2 diabetes. In one case, clinical exam revealed neovascularization elsewhere (NVE) in temporal macula of the left eye. OMAG of the left eye revealed multiple lesions that breached the ILM and blood flow was detected in all NVEs (Figure 1, left). In a second case, multiple NVEs appeared inactive on clinical exam, and OMAG revealed multiple NVEs without blood flow (Figure 1, right). In a third case, clinical exam showed new active neovascularization superotemporal and temporal to the macula. Late FA showed profuse leakage from both areas of NVE. OMAG confirmed the presence of a “bow-tie” shaped frond of neovascularization with active blood flow superotemporal to the macula and an irregular branching network also with active blood flow temporal to the macula.

 
Conclusions
 

This study highlights the OMAG characteristics of diabetic neovascularization elsewhere. With blood perfusion information, OMAG supports the clinical diagnosis of either active or inactive NVEs, suggesting that OMAG can provide information on PDR including the blood flow characteristics within the neovascular complex.  

 
Depth encoded OMAG images of (top left) active NVE and (top right) inactive NVE, with (bottom) OCT intenstiy B-scans. Inner (red), deeper (green), and vessels outside the ILM (purple).
 
Depth encoded OMAG images of (top left) active NVE and (top right) inactive NVE, with (bottom) OCT intenstiy B-scans. Inner (red), deeper (green), and vessels outside the ILM (purple).

 
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