June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Isolated human lens shape determined by tridimensional digital shadowphotogrammetry: A pilot study
Author Affiliations & Notes
  • Ashik Mohamed
    Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India
    School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia
  • Heather Ann Durkee
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Miami, FL
  • Arthur Ho
    School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia
    Vision Cooperative Research Centre, Brien Holden Vision Institute, Sydney, NSW, Australia
  • Virender S Sangwan
    Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India
    Vision Cooperative Research Centre, Brien Holden Vision Institute, Sydney, NSW, Australia
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
    Vision Cooperative Research Centre, Brien Holden Vision Institute, Sydney, NSW, Australia
  • Robert C Augusteyn
    School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia
    Vision Cooperative Research Centre, Brien Holden Vision Institute, Sydney, NSW, Australia
  • Footnotes
    Commercial Relationships Ashik Mohamed, None; Heather Durkee, None; Fabrice Manns, None; Arthur Ho, None; Virender Sangwan, None; Jean-Marie Parel, None; Robert Augusteyn, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 6000. doi:
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      Ashik Mohamed, Heather Ann Durkee, Fabrice Manns, Arthur Ho, Virender S Sangwan, Jean-Marie A Parel, Robert C Augusteyn; Isolated human lens shape determined by tridimensional digital shadowphotogrammetry: A pilot study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):6000.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To examine the curvature of the anterior and posterior surfaces of isolated human crystalline lenses using a digital mini-shadowphotogrammetric system.

 
Methods
 

Crystalline lenses (n = 103, aged 1 month to 88 years, median post-mortem time 26 hours) were isolated from eyes received from the Ramayamma International Eye Bank, Hyderabad, India. Axial thickness, equatorial diameter and surface curvatures (central 3 mm) were calculated from coronal and sagittal profiles of the lenses imaged using a custom-built shadowphotogrammetric system (Mohamed et al, IOVS 2014;55: E-Abstract 747) (Fig. 1). The data were analyzed as a function of age using regression analysis.

 
Results
 

For the younger lenses (aged 1 month to 5 years), the anterior (3.99 ± 0.61 mm) and posterior (4.16 ± 0.74 mm) radii of curvature (R) were independent of age (p>0.05). There was no significant difference between the anterior and posterior radii of curvature in young lenses (p = 0.71, Paired t-test). For older lenses (aged 14 to 88 years), the anterior radius (8.74 ± 2.22 mm) was independent of age (p>0.05), whereas the posterior radius showed a significant increase with age (R = 4.94 + 0.02*Age, p = 0.0003). In these lenses, the anterior radius was significantly larger than the posterior radius (p<0.0001, Wilcoxon signed-rank test). The ratio of anterior radius to posterior radius showed no age dependency (p>0.05) in both young (0.99 ± 0.24) and adult (1.51 ± 0.37) lenses, the difference between the two groups being significant (p = 0.001, Mann-Whitney test) (Fig. 2). Thickness (T) decreases from ~5.4 mm during infancy to ~4.2 mm by 5 years, and increases significantly with age from 14 to 88 years (T = 3.79 + 0.01*x, p<0.0001). The diameter shows an exponential relationship with age (y = 7.21x0.07).

 
Conclusions
 

The human crystalline lens anterior and posterior surface curvatures are quasi equal in very young isolated lenses. Lens curvatures stabilize around age 14.  

 
Representative Coronal and Sagittal Images
 
Representative Coronal and Sagittal Images
 
 
The ratio of anterior radius to posterior radius as a function of age
 
The ratio of anterior radius to posterior radius as a function of age

 
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