June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Accommodative response to electrical stimulation of the sclera of peripheral cornea in cats and porcines
Author Affiliations & Notes
  • Toshifumi Mihashi
    Innovative Research Initiatives, Tokyo Institute of Technology, Yokohama, Japan
  • Yoko Hirohara
    Product Technology Sec., Topcon Corp., Itabashi, Japan
    Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
  • Tomomitsu Miyoshi
    Department of Integrative Physiology, Osaka University Graduate School of Medicine, Suita, Japan
  • Suguru Miyagawa
    Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
    Fundamental Technology Sec., Topcon Corp., Itabashi, Japan
  • Hiroyuki Kanda
    Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
  • Hajime Sawai
    Department of Integrative Physiology, Osaka University Graduate School of Medicine, Suita, Japan
  • Takashi Fujikado
    Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan
  • Thomas Drew
    School of Life and Health Sciences, Aston University, Birmingham, United Kingdom
  • James Stuart Wolffsohn
    School of Life and Health Sciences, Aston University, Birmingham, United Kingdom
  • Footnotes
    Commercial Relationships Toshifumi Mihashi, Topcon Corp. (F); Yoko Hirohara, Topcon Corp. (E); Tomomitsu Miyoshi, None; Suguru Miyagawa, Topcon Corp. (E); Hiroyuki Kanda, None; Hajime Sawai, None; Takashi Fujikado, None; Thomas Drew, Johnson and Johnson (F); James Wolffsohn, Johnson and Johnson (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 6005. doi:https://doi.org/
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      Toshifumi Mihashi, Yoko Hirohara, Tomomitsu Miyoshi, Suguru Miyagawa, Hiroyuki Kanda, Hajime Sawai, Takashi Fujikado, Thomas Drew, James Stuart Wolffsohn; Accommodative response to electrical stimulation of the sclera of peripheral cornea in cats and porcines. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):6005. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: We have reported that the changes in the accommodative response to electrical stimulation of the branches of the ciliary nerves in cats. (Miyagawa et al, PLoS One, 2014). We have also reported that no robust accommodative responses to the electrical stimulations of the sclera of peripheral cornea (SSPC) were observed in enucleated porcine eyes (Mihashi et al, VPOptics, 2014). In this study, accommodative responses to SSPC stimulation in cats and porcines were investigated.

Methods: Two eyes of two cats under anesthesia and after they were sacrificed were studied. Three enucleated porcine eyes obtained from a local slaughterhouse were also studied. Trains of biphasic pulses (current, 3 mA; duration, 2 ms/phase; frequency, 40 Hz) were applied using a tungsten electrode (0.3mm diameter) from several orientations. Wavefront sensing with a compact wavefront aberrometer (Uday et al J Cataract Refract Surg, 2013) were performed before and 4 s (cat) and 10 s (pig) after the stimulations and wavefront aberrations including spherical errors were analyzed over a 4-mm pupil area.

Results: In the first cat under anesthesia, at three out of seven stimulus positions, 0.2 D hyperopic accommodative responses were observed and in two orientations, myopic responses were observed. For the other cat, weak accommodative responses including astigmatic changes were observed. In the sacrificed condition of the second cat, 0.1 D myopic response was observed for one stimulus orientation and the smaller responses were observed at six out of eight stimulus positions. No accommodative responses were elicited for the enucleated porcine eyes.

Conclusions: In the anesthetized cats, electrical stimulation of the SSPC induced accommodative responses; the responses were unstable and weaker than the responses by the ciliary nerve stimulations we observed in our previous study. Small accommodative responses were observed after one of two cats had been sacrificed, but no accommodative responses were detected in the enucleated porcine eyes. Further studies are needed to confirm difference in the accommodation functions in the two species.

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