June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Release of ciprofloxacin and moxifloxacin from daily disposable contact lenses using an in vitro eye model
Author Affiliations & Notes
  • Magdalena Bajgrowicz
    Departement of Mechanics, Materials Science and Engineering, Wroclaw Univeristy of Technology, Wroclaw, Poland
  • Chau-Minh Phan
    Vision Science, University of Waterloo, Waterloo, ON, Canada
  • Lakshman N Subbaraman
    Vision Science, University of Waterloo, Waterloo, ON, Canada
  • Lyndon William Jones
    Vision Science, University of Waterloo, Waterloo, ON, Canada
  • Footnotes
    Commercial Relationships Magdalena Bajgrowicz, None; Chau-Minh Phan, None; Lakshman Subbaraman, None; Lyndon Jones, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 6085. doi:
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      Magdalena Bajgrowicz, Chau-Minh Phan, Lakshman N Subbaraman, Lyndon William Jones; Release of ciprofloxacin and moxifloxacin from daily disposable contact lenses using an in vitro eye model. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):6085.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To analyze the release of two fluoroquinolones, ciprofloxacin and moxifloxacin, from conventional hydrogel (CH) and silicone hydrogel (SH) daily disposable commercial contact lenses (CLs) from a vial and an in vitro eye model.

Methods: Four CH CLs (nelfilcon A, omafilcon A, etafilcon A, ocufilcon B) and three SH CLs (somofilcon A, narafilcon A, delefilcon A) were incubated in a solution containing either ciprofloxacin or moxifloxacin for 24 h. After the incubation period, the lenses were placed in two release conditions: (1) a vial containing 4.8 mL of PBS for 24 hours and (2) an in vitro eye model with a PBS flow rate at 4.8 mL over 24 h. The amount of drugs released was determined using spectrophotometric technique.

Results: The release in the vial for both drugs was very rapid, and reached a plateau between 15 min and 2 h for all lens types. In contrast, under under physiological flow conditions, a constant and slow release was observed over 24 h. The amounts of ciprofloxacin released from the lenses ranged between 49.6±0.7 to 62.8±0.3 µg/lens in the vial, and between 35.0±7.0 to 109.0±5.0 µg/lens in the eye model. Moxifloxacin release ranged from 24.0±4.0 to 226.0±2.0 µg/lens for the vial, and between 13.0±2.0 to 151.0±10.0 µg/lens in the eye model. In both systems and for both drugs, HEMA-based CLs released significantly more drug than other materials.

Conclusions: The parameters of the release system, in particular the volume of the release medium and flow rate, have a huge influence on release profiles. Under physiological flow conditions, release profiles were significantly slower and constant when compared with release in a vial model. The release is also affected by the material composition of the lens, and the water solubility of the drug.

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