June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Quantitative Analysis of Vitreous Inflammation using Optical Coherence Tomography in Patients Receiving Sub-Tenon’s Triamcinolone for Uveitic Cystoid Macular Edema
Author Affiliations & Notes
  • Trystan Macdonald
    Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
  • Pearse Andrew Keane
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • Sreekantam Sreekanth
    Birmingham & Midland Eye Centre, Sandwell and West Birmingham NHS Trust, Birmingham, United Kingdom
  • Dawn A Sim
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • Philip Ian Murray
    Centre for Translational Inflammation Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
  • Alastair K Denniston
    Centre for Translational Inflammation Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
  • Footnotes
    Commercial Relationships Trystan Macdonald, None; Pearse Keane, None; Sreekantam Sreekanth, None; Dawn Sim, None; Philip Murray, None; Alastair Denniston, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 6166. doi:
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      Trystan Macdonald, Pearse Andrew Keane, Sreekantam Sreekanth, Dawn A Sim, Philip Ian Murray, Alastair K Denniston; Quantitative Analysis of Vitreous Inflammation using Optical Coherence Tomography in Patients Receiving Sub-Tenon’s Triamcinolone for Uveitic Cystoid Macular Edema. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):6166.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To obtain measurements of vitreous signal intensity from optical coherence tomography (OCT) image sets in patients with uveitic cystoid macular edema (CME), before and after treatment with sub-Tenon’s triamcinolone, with the aim of developing a novel, objective, quantitative biomarker of treatment response.

 
Methods
 

In this retrospective longitudinal case-series, 13 patients (13 eyes), with CME secondary to intermediate, posterior, or panuveitis, were included. In each case, uveitic CME was treated with sub-Tenon’s triamcinolone injection, and spectral domain OCT images were acquired before and at first follow-up visit after treatment. Clinical and demographic characteristics were recorded in each case. Spectral domain OCT images were analyzed using custom software. This software provided an “absolute” measurement of vitreous signal intensity, which was then compared to that of the retinal pigment epithelium (RPE), generating an optical density ratio with arbitrary units (“VIT/RPE-Relative Intensity”).

 
Results
 

Mean patient age at baseline was 47.32 ± 15.78 years. First follow-up examination after treatment occurred at 54 ± 18 days (median: 51 days; range 28-98 days). VIT/RPE-Relative Intensity was significantly reduced following treatment with triamcinolone (baseline: 0.1455 ± 0.0853 versus first follow-up: 0.0565 ± 0.0311, p = 0.0030).

 
Conclusions
 

OCT-derived measurements of vitreous signal intensity may be useful as an outcome measure in patients with uveitis. It may be possible for such measures to serve as objective, quantitative disease activity endpoints, for the assessment of differential pharmacodynamic effects and clinical outcomes in clinical trials for uveitic CME.

 
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