June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Evaluation of retinal microvasculature in uveitic macular edema using Optical Coherence Tomography Angiography.
Author Affiliations & Notes
  • Noa Fernandez Ledo
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Dawn A Sim
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Pearse Andrew Keane
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Adnan Tufail
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Catherine A Egan
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Marcus Fruttiger
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Nelida Sanz
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Carlos E Pavesio
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Richard W J Lee
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Mark C Westcott
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships Noa Fernandez Ledo, None; Dawn Sim, None; Pearse Keane, None; Adnan Tufail, None; Catherine Egan, None; Marcus Fruttiger, None; Nelida Sanz, None; Carlos Pavesio, None; Richard Lee, None; Mark Westcott, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 6172. doi:
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      Noa Fernandez Ledo, Dawn A Sim, Pearse Andrew Keane, Adnan Tufail, Catherine A Egan, Marcus Fruttiger, Nelida Sanz, Carlos E Pavesio, Richard W J Lee, Mark C Westcott; Evaluation of retinal microvasculature in uveitic macular edema using Optical Coherence Tomography Angiography.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):6172.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the retinal microvasculature in eyes with uveitic macular edema using optical coherence tomography (OCT) angiography

 
Methods
 

OCT angiography images (AngioVue, Optovue) were acquired within a 3x3mm area in the central macula from patients with intermediate uveitis and divided into three groups: active, resolved, and no macular edema. The flow imaging was based on split-spectrum amplitude decorrelation angiography (SSADA), which assesses the vasculature in distinct layers of the retina. The layers assessed were the superficial retinal vascular plexus, deep retinal vascular plexus, avascular outer retina, and choriocapillaris

 
Results
 

25 eyes from 14 patients were included: 8 eyes had active macular edema, 5 resolved macular edema, and 12 no macular edema. Differences within the parafoveal vasculature were observed in eyes with active and resolved macular edema compared to uveitic eyes without macular edema. In eyes with active or resolved macular edema, there was a loss of the normal tapering of vessels feeding the macular area from the temporal vascular arcade. These vessels also appeared more irregular and tortuous compared to uveitic eyes without macular edema. Furthermore, a reduction of capillary density was observed in both superficial and deep retinal vascular plexus. Examination of the choriocapillaris in eyes with macular edema was precluded by the masking effect of the retinal cysts.

 
Conclusions
 

In this case series, we have observed changes in both superficial and deep vascular plexus layers in eyes with both active and resolved uveitic macular edema.<br /> OCT angiography can not only detect the presence of macular ischemia but may also be a useful tool for the management of patients with intermediate uveitis.  

 
Superficial and deep vascular plexus OCT angiography showing tortuous and irregular vessels with reduction in capillary density in eye with uveitic macular oedema
 
Superficial and deep vascular plexus OCT angiography showing tortuous and irregular vessels with reduction in capillary density in eye with uveitic macular oedema
 
 
Superficial and deep vascular plexus OCT angiography in uveitic eye with healthy macula
 
Superficial and deep vascular plexus OCT angiography in uveitic eye with healthy macula

 
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