June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Chorioretinal Biopsy yields a high rate of diagnosis in Intraocular Tumors Masquerading as Uveitis.
Author Affiliations & Notes
  • Rodolfo Mastropasqua
    Vitreo-Retinal, Moorfields Eye Hospital, London, United Kingdom
  • Yvonne Luo
    Vitreo-Retinal, Moorfields Eye Hospital, London, United Kingdom
  • Lyndon da Cruz
    Vitreo-Retinal, Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships Rodolfo Mastropasqua, None; Yvonne Luo, None; Lyndon da Cruz, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 6173. doi:
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      Rodolfo Mastropasqua, Yvonne Luo, Lyndon da Cruz; Chorioretinal Biopsy yields a high rate of diagnosis in Intraocular Tumors Masquerading as Uveitis.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):6173.

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Abstract
 
Purpose
 

To assess the clinical usefulness of chorioretinal biopsy in establishing a definitive diagnosis in intraocular tumors masquerading as uveitis.

 
Methods
 

A retrospective review of a 15-year period was undertaken of all patients that have undergone to chorioretinal biopsy at Moorfields Eye Hospital, London, United Kingdom. Patients were identified on the hospital’s computerized database.

 
Results
 

Twenty-five (89%) of the 28 biopsies performed in an attempt to confirm or exclude malignancy were successful in doing this and often allowed a specific treatment. A specific histological diagnosis was made in 15 cases while in 11 cases the biopsy was effective to exclude malignancy. In the 7 remaining cases, no specific diagnosis was confirmed. No perioperative complications were reported. Postoperative complications related to the surgery included 2 vitreous haemorrages and 2 retinal detachments.

 
Conclusions
 

Chorioretinal biopsy can often resolve diagnosis in difficult clinical settings when less invasive techniques have failed.  

 
Case. Creamy subretinal deposits in a patient with suspected intraocular lymphoma
 
Case. Creamy subretinal deposits in a patient with suspected intraocular lymphoma
 
 
Case. Histologic result. Pleomorphic tumour cells (blue arrow) lying between the RPE (black arrow) and the underlying choroid. The choroid has a reactive infiltrate of small non-neoplastic lymphocytes (green arrow)
 
Case. Histologic result. Pleomorphic tumour cells (blue arrow) lying between the RPE (black arrow) and the underlying choroid. The choroid has a reactive infiltrate of small non-neoplastic lymphocytes (green arrow)

 
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